Martijn A. Spruit

Frits M. E. Franssen7
Emiel FM Wouters7
7Frits M. E. Franssen
7Emiel FM Wouters
4Frits ME Franssen
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BACKGROUND Elevated circulating levels of C-reactive protein (CRP), interleukin (IL)-6 and fibrinogen (FG) have been repeatedly associated with many adverse outcomes in patients with chronic obstructive pulmonary disease (COPD). To date, it remains unclear whether and to what extent systemic inflammation is primary or secondary in the pathogenesis of COPD.(More)
BACKGROUND Polypharmacy of respiratory medications is commonly observed in patients with chronic obstructive pulmonary disease (COPD). The aims of this study were to investigate determinants of polypharmacy and to study the consistency of actual respiratory drug use with current Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines in(More)
BACKGROUND To date, detailed analyses of walking patterns using accelerometers during the 6-min walk test (6MWT) have not been performed in patients with chronic obstructive pulmonary disease (COPD). Therefore, it remains unclear whether and to what extent COPD patients have an altered walking pattern during the 6MWT compared to healthy elderly subjects. (More)
BACKGROUND In patients with COPD progressive dyspnoea leads to a sedentary lifestyle. To date, no studies exist investigating the effects of Nordic Walking in patients with COPD. Therefore, the aim was to determine the feasibility of Nordic Walking in COPD patients at different disease stages. Furthermore we aimed to determine the short- and long-term(More)
BACKGROUND Longitudinal studies analyzing the correlations between disease-specific and generic health status questionnaires at different time points in patients with advanced COPD are lacking. The aim of this study was to determine whether and to what extent a disease-specific health status questionnaire (Saint George's Respiratory Questionnaire, SGRQ)(More)
PURPOSE Aims of this cross-sectional study were to assess health status and care dependency in patients with advanced chronic obstructive pulmonary disease (COPD) or chronic heart failure (CHF) and to identify correlates of an impaired health status. METHODS The following outcomes were assessed in outpatients with advanced COPD (n = 105) or CHF (n = 80):(More)
Background. Osteoporosis is an extrapulmonary effect of chronic obstructive pulmonary disease (COPD). Diagnosis of osteoporosis is based on BMD measured by DXA-scan. The best location for BMD measurement in COPD has not been determined. Aim of this study was to assess whole-body BMD and BMD of the hip and lumbar spine (local DXA) in COPD patients and(More)
  • Vasileios Andrianopoulos, Scott S Wagers, Miriam TJ Groenen, Lowie E Vanfleteren, Frits ME Franssen, Frank WJM Smeenk +3 others
  • 2014
BACKGROUND Exercise tolerance can be assessed by the cycle endurance test (CET) and six-minute walk test (6MWT) in patients with Chronic Obstructive Pulmonary Disease (COPD). We sought to investigate the characteristics of functional exercise performance and determinants of the CET and 6MWT in a large clinical cohort of COPD patients. METHODS A dataset of(More)
  • Fiona A H M Cleutjens, Emiel F M Wouters, Jeanette B Dijkstra, Martijn A Spruit, Frits M E Franssen, Lowie E G W Vanfleteren +2 others
  • 2014
INTRODUCTION Intact cognitive functioning is necessary for patients with chronic obstructive pulmonary disease (COPD) to understand the value of healthy lifestyle guidelines, to make informed decisions and subsequently act on it. Nevertheless, brain abnormalities and cognitive impairment have been found in patients with COPD. To date, it remains unknown(More)
  • Marie-Kathrin Breyer, Martijn A. Spruit, Corrine K. Hanson, Frits M. E. Franssen, Lowie E. G. W. Vanfleteren, Miriam T. J. Groenen +3 others
  • 2014
BACKGROUND The prevalence of metabolic syndrome in COPD patients and its impact on patient related outcomes has been little studied. We evaluated the prevalence of metabolic syndrome and clinical and functional characteristics in patients with COPD and healthy subjects. METHODS 228 COPD patients and 156 healthy subjects were included. Metabolic syndrome(More)