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Behavioral and quantitative electroencephalography (EEG) techniques were used to evaluate treatment response to stimulant therapy in children with attention disorders. A sample of 130 children with attention disorders were evaluated with Conners and Diagnostic and Statistical Manual of Mental Disorders--III rating scales, and with neurometric quantitative(More)
This study identified and characterized a group of schizophrenic patients without neuropsychological (NP) impairment. A comprehensive NP battery was administered to 171 schizophrenic outpatients and 63 normal comparison participants. Each participant's NP status was classified through blind clinical ratings by 2 experienced neuropsychologists; 27% of the(More)
OBJECTIVE The goal was to compare clinical and neuropsychological characteristics of patients with late-onset schizophrenia, a poorly studied and controversial entity, with those of patients with early-onset schizophrenia and normal subjects. METHOD The authors evaluated 25 patients who met DSM-III-R criteria as well as their own research criteria for(More)
OBJECTIVE This study compared morphometric analyses of brain regions in elderly subjects with early- or late-onset schizophrenia to identify structural abnormalities responsible for schizophrenia. METHOD Quantitative analyses of magnetic resonance images of the brain were performed in 16 patients with DSM-III-R-diagnosed late-onset schizophrenia (i.e.,(More)
BACKGROUND Recent interest in suicide rates in schizophrenia has been considerable. AIMS To establish the lifetime suicide rate from the pre-chlorpromazine era and to compare this with recent lifetime suicide rates for schizophrenia. METHOD We have compared suicide and suicide attempt rates for 741 admissions for schizophrenia and 1303 admissions for(More)
Elderly patients with schizophrenia and dementia patients with agitation are frequently candidates for antipsychotic treatment. Conventional neuroleptics have relatively little effect on negative symptoms and may cause considerable side effects, especially in elderly patients. The authors have found a 29% cumulative annual incidence of tardive dyskinesia(More)
BACKGROUND Neuroleptic-induced tardive dyskinesia (TD) is a major iatrogenic disorder that is more prevalent among older patients. The objective of this study was to determine the incidence of and risk factors for TD in neuroleptic-treated patients over age 45 years. METHODS We studied 266 middle-aged and elderly outpatients with a median duration of 21(More)
We present a measurement of the sky distribution of positronium (Ps) annihilation continuum emission obtained with the SPI spectrometer on board ESA's INTEGRAL observatory. The only sky region from which significant Ps continuum emission is detected is the Galactic bulge. The Ps continuum emission is circularly symmetric about the Galactic centre, with an(More)
The authors evaluated 14 middle-aged and elderly patients with delusional disorder (DD) and 253 patients with schizophrenia (SC); all patients met DSM-III-R criteria. Because the DD patients were older and had a later age at onset of illness, a sub-sample of 50 SC patients with illness onset after age 40 was compared with the 14 DD patients on clinical and(More)
Previous studies have reported that a proportion of younger schizophrenic patients have the "deficit syndrome," with persistent "negative" symptoms not secondary to factors other than the disease process (e.g., depression). Yet, there is scant information on the deficit syndrome in older schizophrenic patients. We studied 46 schizophrenic patients over age(More)