• Publications
  • Influence
Activation of the Unfolded Protein Response in Infarcted Mouse Heart and Hypoxic Cultured Cardiac Myocytes
Endoplasmic reticulum (ER) stresses that reduce ER protein folding activate the unfolded protein response (UPR). One effector of the UPR is the transcription factor X-box binding protein-1 (XBP1),Expand
  • 266
  • 14
  • PDF
Activation of Notch-Mediated Protective Signaling in the Myocardium
The Notch network regulates multiple cellular processes, including cell fate determination, development, differentiation, proliferation, apoptosis, and regeneration. These processes are regulated viaExpand
  • 159
  • 13
Evolution of the c‐kit‐Positive Cell Response to Pathological Challenge in the Myocardium
Cumulative evidence indicates that myocardium responds to growth or injury by recruitment of stem and/or progenitor cells that participate in repair and regenerative processes. UnequivocalExpand
  • 127
  • 5
Nuclear and mitochondrial signalling Akts in cardiomyocytes.
Biological actions resulting from phosphoinositide synthesis trigger multiple downstream signalling cascades by recruiting proteins with pleckstrin homology domains, includingExpand
  • 64
  • 3
Myocardial Induction of Nucleostemin in Response to Postnatal Growth and Pathological Challenge
Stem cell–specific proteins and regulatory pathways that determine self-renewal and differentiation have become of fundamental importance in understanding regenerative and reparative processes in theExpand
  • 39
  • 3
Akt Promotes Increased Cardiomyocyte Cycling and Expansion of the Cardiac Progenitor Cell Population
Activation of Akt is associated with enhanced cell cycling and cellular proliferation in nonmyocytes, but this effect of nuclear Akt accumulation has not been explored in the context of theExpand
  • 106
  • 2
Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel.
Voltage-gated L-type Ca(2+) channels (LCCs) provide Ca(2+) ingress into cardiac myocytes and play a key role in intracellular Ca(2+) homeostasis and excitation-contraction coupling. We investigatedExpand
  • 28
  • 1
Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes.
The phosphoinositide 3-kinase (PI3K)/phosphoinositide dependent kinase 1 (PDK1) signaling pathway exerts cardioprotective effects in the myocardium through activation of key proteins including Akt.Expand
  • 17
Progenitor Cell Population Akt Promotes Increased Cardiomyocyte Cycling and Expansion of the Cardiac
Activation of Akt is associated with enhanced cell cycling and cellular proliferation in nonmyocytes, but this effect of nuclear Akt accumulation has not been explored in the context of theExpand
Evolución de la atención en una sala de cuidados intensivos neonatales
Se estudiaron los resultados de la atencion en una sala de Cuidados Intensivos Neonatales de un Hospital Pediatrico de Alta Complejidad (Hospital de Ninos ¨ Superiora Sor Maria Ludovica ¨, La Plata)Expand