Marta Magdalena Suárez

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Throughout the lifespan, the brain has a considerable degree of plasticity and can be strongly influenced by sensory input from the outside environment. Given the importance of the environment in the regulation of the brain structure, behavior and physiology, the aim of the present work was to analyze the effects of different environmental qualities during(More)
Maternal separation can interfere with growth and development of the brain and represents a significant risk factor for adult psychopathology. In rodents, prolonged separation from the mother affects the behavioral and endocrine responses to stress for the lifetime of the animal. Limbic structures such as the anterodorsal thalamic nuclei (ADTN) play an(More)
Repeated separation of dams from their pups during the postpartum period may evoke emotional stress in the dam. In the present study we investigated whether prolonged maternal separation is stressful for rat dams by studying different behavioral and central responses known to be affected by stress. After delivery, female Wistar rats were subjected to either(More)
There is increasing evidence that early adverse experience contributes to the development of stress susceptibility, and increases the onset of stress-related psychiatric disorders in stressful environments in adulthood. This study addressed whether or not prolonged maternal separation, a well-established model of early stress, affects adult limbic areas(More)
The aim of the present study was to investigate the influence of early maternal separation on Fos, arginine vasopressin (AVP) and glucocorticoid receptor (GR) expression in the medial parvocellular portion of the paraventricular hypothalamic nucleus (PaMP), and GR expression in the hippocampus of adult male and female rats subjected to variable chronic(More)
The aim of this work was to determine the effect of amitriptyline (AMI) on peripheral outcomes such as plasma epinephrine (E) and norepinephrine (NE) concentration and anxiety-like behavior displayed in the plus maze test in adult male Wistar rats under variable chronic stress and daily oral administration of AMI (5 mg/kg). Animals were previously isolated(More)
The aim of the present study was to determine the effects of chronic treatment with the antidepressant amitriptyline on sympathetic nervous system activity and anxiety in male and female rats submitted to maternal separation (MS) and variable chronic stress (VCS). We observed that the treatment with amitriptyline produced a significant increase in(More)
The pituitary-adrenal axis response is gender-dependent, showing lower activity in male rats. Furthermore, males showed low emotional behavior and females high emotionality when exposed to such chronic stress situations. The gender of an animal is a relevant factor in the development of responses to stress. The aim of the present study was to investigate(More)
The hypothalamic-pituitary-adrenal (HPA) axis is normally regulated by extrahypothalamic limbic structures, among these, the anterodorsal thalami nuclei (ADTN), which exert an inhibitory influence on HPA, in basal and acute stress conditions in rats. In the present work we have investigated whether neonatal maternal deprivation (MD) produces long-term(More)
There is evidence that repeated maternal isolation of neonatal rats may influence both emotional behavior and Hypothalamic-Pituitary Adrenal (HPA) activity. On the other hand the Anterodorsal Thalami Nuclei (ADTN) exerts an inhibitory influence on the hypophyso-adrenal system under basal and stressful conditions. In the present work we investigated whether(More)