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  • Massimo Federici, Rossella Menghini, +7 authors Renato Lauro
  • Medicine
  • Circulation
  • 2002 (First Publication: 23 July 2002)
  • BACKGROUND Hyperglycemia impairs functional properties of cytosolic and nuclear proteins via O-linked glycosylation modification (O-GlcNAcylation). We studied the effects of O-GlcNAcylation onContinue Reading
  • Giorgio Sesti, Massimo Federici, Marta Letizia Hribal, Davide Lauro, Paolo Sbraccia, Renato Lauro
  • Medicine, Biology
  • FASEB journal : official publication of the…
  • 2001 (First Publication: 1 October 2001)
  • Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling and play a central role in maintaining basic cellular functions such as growth, survival, and metabolism. They act asContinue Reading
  • Massimo Federici, Marta Letizia Hribal, +16 authors Franco Folli
  • Biology, Medicine
  • Diabetes
  • 2001 (First Publication: 1 June 2001)
  • Type 2 diabetes is characterized by insulin resistance and inadequate insulin secretion. In the advanced stages of the disease, beta-cell dysfunction worsens and insulin therapy may be necessary toContinue Reading
  • Francesca Bernassola, Massimo Federici, +10 authors Gerry Melino
  • Medicine, Biology
  • FASEB journal : official publication of the…
  • 2002 (First Publication: 1 September 2002)
  • Transglutaminase 2 (TGase 2) is a Ca+2-dependent enzyme that catalyzes both intracellular and extracellular cross-linking reactions by transamidation of specific glutamine residues. TGase 2 is knownContinue Reading
  • Marta Letizia Hribal, Jun Nakae, Tadahiro Kitamura, John R. Shutter, Domenico Accili
  • Medicine, Biology
  • The Journal of cell biology
  • 2003 (First Publication: 18 August 2003)
  • Insulin-like growth factors promote myoblast differentiation through phosphoinositol 3-kinase and Akt signaling. Akt substrates required for myogenic differentiation are unknown. ForkheadContinue Reading
  • Maria Adelaide Marini, Elena Succurro, +5 authors Giorgio Sesti
  • Medicine
  • Diabetes care
  • 2007 (First Publication: 1 August 2007)
  • Obesity is associated with metabolic and cardiovascular risk factors that include type 2 diabetes, hypertension, and dyslipidemia (1–4). A subset of obese subjects has been identified that appears toContinue Reading
  • Markku Laakso, J. Žilinskaitė, +15 authors for the EUGENE2 Consortium
  • Biology, Medicine
  • Diabetologia
  • 2007 (First Publication: 1 March 2008)
  • Aims/hypothesisWe examined the phenotype of individuals with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) with regard to insulin release and insulinContinue Reading
  • Rossella Menghini, Valentina Marchetti, +6 authors Massimo Federici
  • Biology, Medicine
  • Circulation
  • 2005 (First Publication: 19 April 2005)
  • BACKGROUND Obesity-related inflammation is emerging as a major cause of insulin resistance and cardiovascular diseases. GATA2 transcription factor is an inhibitor of adipogenesis and an activator ofContinue Reading