Marta Jessica Jakobisiak

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Lovastatin (LOV), the drug recently introduced to treat hypercholesteremia, inhibits the synthesis of mevalonic acid. The effects of LOV on the cell cycle progression of the human bladder carcinoma T24 cell line expressing activated p21ras were investigated. At a concentration of 2-10 microM, LOV arrested cells in G1 and also prolonged--or arrested a minor(More)
The <italic>Context Interchange</italic> strategy presents a novel approach for mediated data access in which semantic conflicts among heterogeneous systems are not identified a priori, but are detected and reconciled by a <italic>context mediator</italic> through comparison of <italic>contexts</italic>. This paper reports on the implementation of a Context(More)
In this thesis, I designed and implemented the Multidatabase Browser and the Wrapper Generator. The Multidatabase Browser is a tool that allows a single query interface to heterogenous sources: relational databases and data published through the World Wide Web. The Browser is a front end application to the Context Interchange Network (COIN). Structured or(More)
Of a number of factors involved in apoptosis, protease activity may play a crucial role. We show that N-benzyloxycarbonyl-Ile-Glu(O-t-butyl)-Ala-leucinal (PSI), a selective inhibitor of the chymotrypsin-like activity of the proteasome, induces massive apoptosis in murine leukaemia L1210 cells. At 50 nM concentration, PSI induces a block of cytokinesis,(More)
Inhibition of the proteasome, a multicatalytic proteinase complex, is an attractive approach to cancer therapy. Here we report that a selective inhibitor of the chymotrypsin-like activity of the proteasome, PSI (N-benzyloxycarbonyl-Ile-Glu(O-t-butyl)-Ala-leucinal) may inhibit growth of solid tumors not only through apoptosis induction, but also(More)
Obese strain chickens, which spontaneously develop autoimmune thyroiditis, were tested for their ability to tolerate skin allografts. Several procedures known to prolong graft survival in normal strains were employed. These included the use of skin matched at the major histocompatibility locus, grafting on the day of hatching, thymectomy, and x-irradiation.(More)
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