Marta Gutierrez

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Propranolol has been used successfully in a limited number of children with infantile hemangiomas. This multicenter retrospective study describes the efficacy and adverse effects of propranolol in infantile hemangioma. Seventy-one infants with infantile hemangiomas were treated with oral propranolol, 1 mg/kg/12 hours, for at least 12 weeks. A photograph(More)
Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We(More)
The Natural Environment Research Council (NERC) DataGrid (NDG) aims to provide a framework for the discovery and use of data needed in NERC research. To support this, the NDG has developed a metadata and data model. The data model is directly concerned with the representation and use of the data, with the metadata model covering the discovery and(More)
The NDG project began in September 2002. The aim of the project is to utilise the promise of grid technologies to allow members of a virtual organisation (the NERC community) to share environmental data held in disparate institutions. The NDG virtual organisation will begin with elements of the oceanographic and atmospheric community, but aims to expand to(More)
Diffuse mesangial sclerosis (DMS) is a renal disease that usually presents as a nephrotic syndrome. It is characterized by early onset and rapid progression to end-stage renal disease, and can occur as an isolated finding or as part of the Denys-Drash syndrome. The aim of this study was to characterize clinical features and outcomes of DMS in a cohort of(More)
Data services for the grid have focussed so far primarily on virtualising access to distributed databases, and encapsulating file location. However, orchestration of services requires richer information semantics than these mechanisms provide. Service inputs and outputs must be semantically matched, or characterised in order that sensible transformations(More)
NERC DataGrid (NDG) will provide discovery of and access to a range of environmental data. Here we describe the deployment of the Reference Model for Open Distributed Processing (RMODP) to architect NDG development. RM-ODP was adopted as a formal architecture methodology because of the close match between Grids and ODP system concepts. The process provides(More)
The EU funded SIMDAT project is aimed at applying generic grid technology for the solution of complex application problems in several representative fields including automotive, aerospace, pharmaceutical and meteorology. To satisfy the requirements of the World Meteorological Organization (WMO) and the WMO Information Systems (WIS), the partners in the(More)
The NERC DataGrid (NDG) project has been investigating vocabularies describing measurements or model outputs for use in its ‘discovery’ and ‘use’ metadata schema. It has been recognised that the two types of metadata have significantly different requirements of this type of vocabulary and therefore that more than one vocabulary is required. Automated(More)
We present a quantitative semiclassical treatment of the effects of bifurcations on the spectral rigidity and the spectral form factor of a Hamiltonian quantum system defined by two coupled quartic oscillators, which on the classical level exhibits mixed phase space dynamics. We show that the signature of a pitchfork bifurcation is two-fold: Beside the(More)
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