Marta Giorgetti

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1. The effects of histamine and agents at histamine receptors on spontaneous and 100 mM K(+)-evoked release of acetylcholine, measured by microdialysis from the cortex of freely moving, rats, and on cognitive tests are described. 2. Local administration of histamine (0.1-100 microM) failed to affect spontaneous but inhibited 100 mM K(+)-stimulated release(More)
Cortical perfusion with GABA agonists and antagonists modulates the spontaneous release of cortical acetylcholine and GABA in freely moving rats. Twenty-four hours after implantation of a dialysis fibre, cerebral cortex spontaneously released acetylcholine (3.8 +/- 0.2 pmol/10 min) and GABA (6.6 +/- 0.4 pmol/10 min) at a stable rate. Local administration of(More)
Through the activation of cortical histamine H3 receptors, histamine has been shown to inhibit acetylcholine release from rat cortex in vivo [1]. This effect is indirect, mediated by cortical GABA interneurons [2]. However, cholinergic nucleus basalis magnocellularis (NBM) neurons, which provide cholinergic innervation to the cortex [3], are excited by(More)
In the brain, H 3 receptors function predominantly as presynaptic inhibitory receptors. Indeed, their activation moderates the in vitro-release of tritiated histamine [1], serotonin [2], noradrenaline [3] and acetylcholine [4]. In vivo, a modulation of hippocampal acetylcholine release through H 2 receptors has been suggested [5]. We now report that(More)
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