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Bone morphogenetic protein (BMP) signaling is essential for neural crest development in several vertebrates. Genetic experiments in the mouse have shown that Bmp2 is essential for the genesis of migratory neural crest cells. Using several markers and a transgenic reporter approach, we now show that neural crest cells are induced in Bmp2 null mutant embryos,(More)
Neural circuit mapping is generating datasets of tens of thousands of labeled neurons. New computational tools are needed to search and organize these data. We present NBLAST, a sensitive and rapid algorithm, for measuring pairwise neuronal similarity. NBLAST considers both position and local geometry, decomposing neurons into short segments; matched(More)
BACKGROUND Anatomy ontologies are query-able classifications of anatomical structures. They provide a widely-used means for standardising the annotation of phenotypes and expression in both human-readable and programmatically accessible forms. They are also frequently used to group annotations in biologically meaningful ways. Accurate annotation requires(More)
Morphogenesis of the zebrafish neural tube requires the coordinated movement of many cells in both time and space. A good example of this is the movement of the cells in the zebrafish neural plate as they converge towards the dorsal midline before internalizing to form a neural keel. How these cells are regulated to ensure that they move together as a(More)
Please note that this preprint is a public draft not a submitted manuscript. It is released in the expectation that it will be useful to our colleagues as is and in order to solicit feedback. All presented results are considered reliable, but it is likely that the final manuscript may contain some additional analysis; for this reason, the byline should not(More)
INTRODUCTION The emergence of a new subtype of the influenza virus in 2009 generated interest in the international medical community, the media, and the general population. Pregnant women are considered to be a group at risk of serious complications related to the H1N1 influenza virus. The aim of this study was to evaluate the outcomes and teratogenic(More)
The distribution of sensory bristles on the thorax of Diptera (true flies) provides a useful model for the study of the evolution of spatial patterns. Large bristles called macrochaetes are arranged into species-specific stereotypical patterns determined via spatially discrete expression of the proneural genes achaete-scute (ac-sc). In Drosophila ac-sc(More)
The Drosophila anatomy ontology (DAO) defines the broad anatomy of the fruitfly Drosophila melanogaster, a genetic model organism. It contains over 8700 classes, with close to half of these corresponding to neuroanatomical terms. We are systematically reviewing the DAO classes, improving the textual information and classification. This includes adding(More)
A massive effort is underway to map the structure of the Drosophila nervous system and to genetically dissect its function. Virtual Fly Brain (VFB; http://www.virtualflybrain.org) is a popular, OWL-based resource providing neuroinformatics support for this work. It provides: curated descriptions of brain regions and neurons; queries for neurons based on(More)
Vertebrates have evolved gills and homologous organ parathy-roid that regulate calcium level in the blood in their different living environments. In higher teleosts, chloride cells in the skin are known to regulate calcium level, yet molecular mechanisms that control development of these cells during the evolution of higher teleosts remain to be(More)
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