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In utero exposure to di-(2-ethylhexyl) phthalate reveals the presence of an adrenal-testis axis regulating androgen formation
The mineralocorticoid receptor (NR3C2; MR) mediates testosterone production and it is shown that in utero exposure to DEHP decreases MR expression in Leydig cells, suggesting that the effects of DEHP are independent of the classic steroidogenic pathway.