Martí Lecina

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Many efforts have been invested in the development of culture strategies for animal cell culture process. Several strategies have been studied: batch, fed-batch and perfu-sion cultures [1]. For implementation of those strategies, a monitoring system for automated, controlled and opti-mised processes based on simple measurement could be of great interest.(More)
Background From 1989 the number of bioprocesses based on mam-malian cell systems has been continuously increasing from 33% of the total number of new drug approvals (up to 1989) to 60% of that number (period 2010-2014) [1]. Due to the high costs of these bioprocesses and the increasing competitiveness in the field, the good characterization and optimization(More)
One of the most important limitations of mammalian cell-based processes is the secretion and accumulation of lactate as a by-product of their metabolism. Among the cell lines commonly used in industrial bioprocesses, HEK293 has been gaining importance over the last years. Up recently, HEK293 cells were known to consume lactate in late stages of cell culture(More)
Background The use of human embryonic kidney cells (HEK293) for recombinant protein or virus production has gained relevance along the last years. They are specially recommended for transient gene expression and adenovirus or adeno-associated virus generation [1,2]. To achieve high volumetric productivities towards bioprocess optimization , the(More)
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