Marshall Devor

Learn More
BACKGROUND We carried out a genome-wide study, using microRNA sequencing (miRNA-seq), aimed at identifying miRNAs in primary sensory neurons that are associated with neuropathic pain. Such scans usually yield long lists of transcripts regulated by nerve injury, but not necessarily related to pain. To overcome this we tried a novel search strategy:(More)
Neuropathic pain is a major, intractable clinical problem and its pathophysiology is not well understood. Although recent gene expression profiling studies have enabled the identification of novel targets for pain therapy, classical study designs provide unclear results owing to the differential expression of hundreds of genes across sham and nerve-injured(More)
1. Describe peripheral mechanisms of neuropathic pain. 2. Explain spinal and brain circuits involved in neuro-pathic pain. 3. Discuss translational aspects of neuropathic pain mechanisms. Introduction Th e International Association for the Study of Pain (IASP) defi nes neuropathic pain as pain that is caused by a lesion or disease of the somatosensory(More)
  • 1