Marshall A Schwartz

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PURPOSE Mouse monoclonal antibody (mAb) M195 (anti-CD33) is reactive with most myeloid leukemia cells, monocytes, and hematopoietic progenitors, but not with other hematopoietic cells or stem cells nor with nonhematopoietic human tissues. A therapeutic dose-escalation study of M195 labeled with iodine 131 was conducted in patients with relapsed or(More)
Many instances of a close relationship between folic acid and ascorbic acid have been reported in the literature. Johnson and Dana (1) have shown that ascorbic acid relieves many of the abnormalities noted in a folic acid deficiency syndrome. Woodruff and Darby (2) have reported that folic acid aids in correcting the abnormal tyrosine metabolism of the(More)
Long-term survival rates of patients with acute myelogenous leukemia treated with intensive chemotherapy are 15-20%, despite efforts to develop new treatment strategies. Murine M195 (131I-M195), an anti-CD33, immunoglobulin (Ig) G2a monoclonal antibody has reactivity restricted to early myeloid cells and myeloid leukemic blasts but not hematopoietic(More)
9053 Background: Quality of Life (QOL) in patients diagnosed with malignant glioma is essential in the care of the patient. Patients often minimize many aspects of QOL; hence, caregiver input is valuable. Given the physical and cognitive decline experienced by malignant glioma patients, the primary caregiver plays a particularly important role in both daily(More)