Marsden S. Blois

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Cu(++), Mn(++), and Fe(+++) account for the electron spin resonances observed in certain samples of ATP and RNA. The copper ion seems more loosely bound to these substances than either iron or manganese. A striking similarity is observed between the manganese spectra in manganese RNA, ATP, and ADP suggesting that the binding sites are similar in the three(More)
After scientists had developed the first digital computers in the 1940s, society was told that these new machines would soon be serving routinely as memory devices, assisting with calculations and with information retrieval. Within the next decade, physicians and other health workers had begun to hear about the dramatic effects that such technology would(More)
A retrospective study was undertaken of local, regional, and distant recurrences in 346 patients with primary melanomas of tumor thickness less than 1.0 mm that were excised with margins of normal skin varying between 0.1 cm and 5.0 cm or more. Prospective histopathologic examination of 284 melanomas for the presence of microsatellites was also performed(More)
To validate the supposition that thin malignant melanomas (less than 0.76 mm thick) of ordinarily low risk but with areas of regression may paradoxically metastasize, we observed 121 thin malignant melanomas over a six year period. Of these, 23 displayed readily apparent areas of regression, of which five (21.7%) metastasized. The incidence of metastases in(More)
A total of 844 cutaneous malignant melanomas were examined prospectively for the presence or absence of histologic regression within the primary tumor. Cases were then stratified into three groups according to tumor thickness and survival was compared between substrata with and without regression in each group. The distribution of other major prognostic(More)
  • M S Blois
  • The Journal of medicine and philosophy
  • 1983
Attempts to formalize the diagnostic process are by no means a recent undertaking; what is new is the availability of an engine to process these formalizations. The digital computer has therefore been increasingly turned to in the expectation of developing systems which will assist or replace the physician in diagnosis. Such efforts involve a number of(More)
This study investigated the relationship between patient delay in seeking medical attention and prognostic indicators, tumor characteristics, and demographic and behavioral factors in 106 patients with cutaneous malignant melanoma. Patients with less readily apparent lesions, particularly on the back, had longer delays in seeking treatment, as might be(More)
Chromatographic analysis of sera or urine is important in medicine for the evaluation of patients whose clinical status is associated with the presence of specific biochemical markers. Malignant melanoma has been a model for such studies due to the elaboration of melanin precursors and pigment as the tumor metastasizes. Computer-assisted methods for(More)