Marry M. van den Heuvel-Eibrink

Rob Pieters4
Jacqueline Cloos2
4Rob Pieters
2Jacqueline Cloos
2Eveline S. J. M. de Bont
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  • Charlotte M. Niemeyer, Michelle W. Kang, Danielle H. Shin, Ingrid Furlan, Miriam Erlacher, Nancy J Bunin +25 others
  • 2010
CBL encodes a member of the Cbl family of proteins, which functions as an E3 ubiquitin ligase. We describe a dominant developmental disorder resulting from germline missense CBL mutations, which is characterized by impaired growth, developmental delay, cryptorchidism and a predisposition to juvenile myelomonocytic leukemia (JMML). Some individuals(More)
Clear Cell Sarcoma of the Kidney (CCSK) is a rare childhood tumor whose molecular pathogenesis remains poorly understood. We analyzed a discovery set of 13 CCSKs for changes in chromosome copy number, mutations, rearrangements, global gene expression and global DNA methylation. No recurrent segmental chromosomal copy number changes or somatic variants(More)
In early childhood, children develop motor skills that form the basis of their future physical activities. This development can stagnate when children face long-term hospitalization due to injury or disease. Most interventions to facilitate their physical development are built on exercise and structured play, and have ignored the value of spontaneous and(More)
Osteonecrosis is a disabling complication of treatment for pediatric acute lymphoblastic leukemia, and much effort has been made to predict which patients are prone to develop this disease. Multiple clinical and genetic factors have already been identified as being associated with osteonecrosis; however, a prediction model that combines pretreatment genetic(More)
  • Lidewij T. Warris, Erica L. T. van den Akker, Marc B. Bierings, Cor van den Bos, Christian M. Zwaan, Sebastiaan D. T. Sassen +4 others
  • 2016
Although dexamethasone is highly effective in the treatment of pediatric acute lymphoblastic leukemia (ALL), it can cause serious metabolic side effects. Because studies regarding the effects of dexamethasone are limited by their small scale, we prospectively studied the direct effects of treating pediatric ALL with dexamethasone administration with respect(More)
Development of relapse remains a problem for further improvements in the survival of pediatric AML patients. While virtually all patients show a good response to initial treatment, more patients respond poorly when treated at relapse. The cellular characteristics of leukemic blast cells that allow survival of initial treatment, relapse development and(More)
One of the most important application spectrums of transcriptomic data is cancer phenotype classification. Many characteristics of transcriptomic data, such as redundant features and technical artifacts, make over-fitting commonplace. Promising classification results often fail to generalize across datasets with different sources, platforms, or(More)
Genomic gain of the proto-oncogene transcription factor gene MYCN is associated with poor prognosis in several childhood cancers. Here we present a comprehensive copy number analysis of MYCN in Wilms tumour (WT), demonstrating that gain of this gene is associated with anaplasia and with poorer relapse-free and overall survival, independent of histology.(More)
  • Mahban Irandoust, Julian Alvarez Zarate, Isabelle Hubeek, Ellen M. van Beek, Karin Schornagel, Aart J. F. Broekhuizen +15 others
  • 2013
BACKGROUND Recent studies show the importance of interactions between CD47 expressed on acute myeloid leukemia (AML) cells and the inhibitory immunoreceptor, signal regulatory protein-alpha (SIRPα) on macrophages. Although AML cells express SIRPα, its function has not been investigated in these cells. In this study we aimed to determine the role of the(More)
BACKGROUND Reports on metabolic syndrome in nephroblastoma and neuroblastoma survivors are scarce. Aim was to evaluate the occurrence of and the contribution of treatment regimens to the metabolic syndrome. PATIENTS AND METHODS In this prospective study 164 subjects participated (67 adult long-term nephroblastoma survivors (28 females), 36 adult long-term(More)