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Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening.
The coupling of virtual screening methodologies with FAC-MS is a unique hybrid approach that can be used to increase the efficacy of both hit discovery and optimization efforts in drug discovery and has successfully identified hits, in particular 19a, as inhibitors for EphB2, a potential cancer target.
Development and Characterization of a Camelid Single Domain Antibody–Urease Conjugate That Targets Vascular Endothelial Growth Factor Receptor 2
- B. Tian, W. Wong, Marni D. Uger, P. Wisniewski, H. Chao
- Biology, ChemistryFront. Immunol.
- 21 August 2017
V21-DOS47 is an immunoconjugate that targets VEGFR2 and can be efficiently generated and purified using methods easily transferrable for cGMP production, and is determined to be the superior conjugate as the antibody is easily produced and purified at high levels.
Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivo model of Alzheimer’s disease
It is demonstrated that microgliosis and astrocytosis are prominent aspects of this AD mouse model and that the model might contribute to the understanding of complex pathological mechanisms and their interplay in AD.
Early detection of β-amyloid aggregation in in vivo and in vitro models of Alzheimer's disease
Abstract 4636: AMF-1c-120: an antibody specific for misfolded prion protein expressed on ovarian cancer cells.
An antibody that is specific for ovarian cancer cells, which does not bind to normal ovarian epithelium is developed, and proteinase K sensitivity of the AMF-1c-120 epitope is consistent with partial denaturation of PrP at the cell surface of ovarian cancer cell lines.
Normal healthy donors possess plasma IgG reactive to a neutralizing epitope for toxic and amyloid-seeding beta-amyloid oligomers
Abstract 1231: Improving survival in pancreatic cancer using Doxorubicin in combination with L-DOS47
O.16: AMF-1c-120: An antibody specific for misfolded prion protein recognizes ovarian and lung cancer cells but not normal cells
Amorfix Epitope Protection-Alzheimer's Disease (EP-AD) diagnostic cerebrospinal fluid test for accurate identification of Alzheimer's disease and mild cognitive impairment
Abstract 3919: Targeting urease to human VEGFR2 elicits antitumor activity in triple-negative breast cancer models