Marla Gómez

Learn More
Poly(ADP-ribose)polymerase 1 (PARP1) is well characterized for its role in base excision repair (BER), where it is activated by and binds to DNA breaks and catalyzes the poly(ADP-ribosyl)ation of several substrates involved in DNA damage repair. Here we demonstrate that PARP1 associates with telomere repeat binding factor 2 (TRF2) and is capable of(More)
The Cdc14 dual-specificity phosphatases regulate key events in the eukaryotic cell cycle. However, little is known about the function of mammalian CDC14B family members. Here, we demonstrate that subcellular localization of CDC14B protein is cell cycle regulated. CDC14B can bind, bundle, and stabilize microtubules in vitro independently of its catalytic(More)
Vault poly(ADP-ribose) polymerase (VPARP) was originally identified as a minor protein component of the vault ribonucleoprotein particle, which may be involved in molecular assembly or subcellular transport. In addition to the association of VPARP with the cytoplasmic vault particle, subpopulations of VPARP localize to the nucleus and the mitotic spindle,(More)
Telomerase deficiency leads to a progressive loss of telomeric DNA that eventually triggers cell apoptosis in human primary cells during prolonged growth in culture. Rare survivors can maintain telomere length through either activation of telomerase or recombination-based telomere lengthening, and thus proliferate indefinitely. We have explored the(More)
This case study describes how an enterprise IT user experience (UX) group evolved from its genesis as a tactical, backend fixer of usability issues to a strategic partner within a large IT department. We share specifics as to how UX emerged as a skillset, how UX professionals evolved their methods to increase their effectiveness, and how operational changes(More)
*Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6445; †Département Intégrité du Génome de l’UMR7175-LC1 du CNRS, Université Louis Pasteur, Ecole Supérieure de Biotechnologie de Strasbourg, 67412 Illkirch Cedex, France; ‡Microscopy Facility, Division of Biology, The University of Tennessee, Knoxville, TN 37996; and §Department of(More)
  • 1