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OBJECTIVE Quetiapine is one of the most frequent prescribed antipsychotics. Based on the consensus guidelines of therapeutic drug monitoring (TDM) in clinical practice, TDM of Quetiapine is "useful". In this pilot study, using a natural sample, we investigated the influence of co-medication, age and gender on the serum concentrations and clearance of(More)
BACKGROUND In this article, we review current data on the prevalence of, risk factors for, and treatment of peripartum depression. METHOD Pertinent publications were retrieved by searches in Medline and the Cochrane Library using the key words "peri/pre/post", "partum/partal/natal", "maternal/motherhood/pregnancy", and "depression/affective disorder". (More)
New algorithms and optimization techniques are needed to balance the accelerating trend towards bandwidth-starved multicore chips. It is well known that the performance of stencil codes can be improved by temporal blocking, lessening the pressure on the memory interface. We introduce a new pipelined approach that makes explicit use of shared caches in(More)
Task parallelism as employed by the OpenMP task construct or some Intel Threading Building Blocks (TBB) components, although ideal for tackling irregular problems or typical produc-er/consumer schemes, bears some potential for performance bottlenecks if locality of data access is important, which is typically the case for memory-bound code on ccNUMA(More)
INTRODUCTION Many psychotropic drugs can delay cardiac repolarization and thereby prolong the rate-corrected QT interval (QTc). A prolonged QTc often arouses concern in clinical practice, as it can be followed, in rare cases, by the life-threatening polymorphic ventricular tachyarrhythmia called torsade de pointes (TdP). METHOD We searched PubMed for(More)
Hypothermia as an adverse reaction of antipsychotic drug use represents a potentially life-threatening complication. However, the mechanisms by which antipsychotic drugs alter thermoregulatory processes in the human body are far from being fully understood. Here we present a case series of 5 patients developing severe hypothermia after administration of(More)
We present a pipelined wavefront parallelization approach for stencil-based computations. Within a fixed spatial domain successive wavefronts are executed by threads scheduled to a multicore processor chip with a shared outer level cache. By re-using data from cache in the successive wavefronts this multicore-aware parallelization strategy employs temporal(More)
Dementia with frontotemporal lobar degeneration (FTLD) is clinically characterized by the occurrence of various psychiatric symptoms. In a recent study, the hospital-based prevalence of FTLD and the circumstances of the patients' admission to German psychiatric state hospitals were estimated. On the basis of further continuous assessment, this original FTLD(More)
Algorithms with low computational intensity show interesting performance and power consumption behavior on multicore processors. We choose the lattice-Boltzmann method (LBM) as a prototype for this scenario in order to show if and how single-chip performance and power characteristics can be generalized to the highly parallel case. LBM is an algorithm for(More)