Markus W. Schulz

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We have shown previously that FGF induces lens epithelial cells in explant culture to proliferate, migrate and differentiate into fibre cells in a progressive concentration-dependent manner. In situ, these processes occur in a distinct anterior-posterior pattern in clearly defined regions of the lens. Thus anterior-posterior differences in the(More)
Spindle-shaped myofibroblast-like cells, which contain alpha-smooth muscle actin, have been described in anterior subcapsular cataract and after-cataract. In a previous study in this laboratory, it was shown that transforming growth factor-beta (TGF beta) induces the formation of spindle-shaped cells in lens epithelial explants. The aim of this(More)
This paper reports on the deployment experience of the de-facto grid information system, Globus MDS (Meta-data Directory Service) [1], in a large scale production grid and how this experience led to the development of an information caching system based on a standard OpenLDAP (Lightweight Directory Access Protocol) [2] database. The paper then describes how(More)
In the mammalian eye, FGF plays a key role in the induction of lens fibre differentiation and, in other systems, heparan sulphate proteoglycans (HSPGs) have been shown to modulate FGF activity. HSPGs were isolated from the anterior and posterior rat and bovine lens capsule and assessed in terms of their ability to bind FGF-1 and FGF-2. In the rat, at least(More)
PURPOSE To investigate the ocular media for the presence of inhibitors of transforming growth factor-beta (TGF beta) using a lens epithelial explant system in which TGF beta induces cataractous changes. The effect of alpha 2-macroglobulin, an inhibitor of TGF beta in other systems, also was assessed. METHODS Explants prepared from 21-day-old rats were(More)
Over recent years a number of Grid projects have emerged which have built Grid infrastructures that are now the computing backbones for various user communities. A significant number of these communities are limited to one Grid Infrastructure due to the different middleware and operations procedures used. Grid Interoperation is trying to bridge these(More)
Grid Information Systems are mission-critical components in today’s production Grid infrastructures. They enable users, applications and services to discover which services exist in the infrastructure and further information about their service structure and state. As the Grid Information System is pervasive throughout a Grid infrastructure, it is(More)
Dissociated neonatal rat retinal ganglion cells can be maintained by the addition of an extract from the neonatal superior colliculus. This extract can support 95% of ganglion cells over 24 h in culture; in addition it promotes the expression of neurites from these cells. This report describes the purification of a neurotrophic factor from the superior(More)
The release of nitric oxide and stimulation of glutamate receptors by excitatory amino acids has been linked to neuronal degeneration and toxicity. In the rat retina approximately 60% of retinal ganglion cells (RGCs) die during the first postnatal week. In this study we examined the effects of nitric oxide synthase blockers and glutamate on the survival of(More)