Markus R Dobler
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Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors.
- L. Whitehead, Markus R Dobler, +14 authors T. Stams
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 August 2011
Herein we report the discovery of a family of novel yet simple, amino-acid derived class I HDAC inhibitors that demonstrate isoform selectivity via access to the internal acetate release channel.… Expand
Identification of orally available naphthyridine protein kinase D inhibitors.
- E. Meredith, Ophelia Ardayfio, +31 authors L. Monovich
- Medicine, Chemistry
- Journal of medicinal chemistry
- 14 July 2010
A novel 2,6-naphthyridine was identified by high throughput screen (HTS) as a dual protein kinase C/D (PKC/PKD) inhibitor. PKD inhibition in the heart was proposed as a potential antihypertrophic… Expand
Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 1: pyrido[2,3-b]pyrazines.
- P. J. Crowley, C. Lamberth, +10 authors Markus R Dobler
- Medicine, Biology
- Pest management science
- 30 September 2009
BACKGROUND The excellent fungicidal activity of [1,2,4]triazolo[1,5-a]pyrimidines suggested the search for further analogues with improved properties. RESULTS A series of novel trisubstituted… Expand
Investigating the Structure-Activity Relationship of the Insecticidal Natural Product Rocaglamide.
The natural product Rocaglamide (1), isolated from the tree Aglaia elliptifolia, is a compelling but also challenging lead structure for crop protection. In laboratory assays, the natural product… Expand
A short and efficient preparation of methyl-[1,2,4]oxadiazolium derivatives with plant-inducing activity.
- Markus R Dobler
- Medicine, Chemistry
- Organic & biomolecular chemistry
- 19 March 2004
We have developed a concise and efficient synthetic method leading to a structurally diverse array of salicylic acid and oxadiazolium derivatives, starting from commercially available halogenated… Expand