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Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair
DNA interstrand crosslinks (ICLs) can be induced by multiple crosslinking agents and are a severe form of DNA damage that prevents strand separation during DNA replication and transcription. FailureExpand
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The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair
Fanconi Cross-Links Fanconi anemia is a rare genetic disease characterized by bone marrow failure, developmental abnormalities, and dramatically increased cancer susceptibility. Cells derived fromExpand
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XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4.
DNA interstrand crosslinks (ICLs), highly toxic lesions that covalently link the Watson and Crick strands of the double helix, are repaired by a complex, replication-coupled pathway in higherExpand
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Mechanism of RAD51-Dependent DNA Interstrand Cross-Link Repair
An in vitro system reveals the steps involved in repairing covalent links between DNA strands of the double helix. DNA interstrand cross-links (ICLs) are toxic DNA lesions whose repair in S phase ofExpand
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Functional analysis of MLH1 mutations linked to hereditary nonpolyposis colon cancer
Hereditary nonpolyposis colon cancer (HNPCC) is associated with malfunction of postreplicative mismatch repair (MMR). While a majority of HNPCC‐associated mutations in the MMR genes MLH1, MSH2, orExpand
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Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts
Summary DNA-protein crosslinks (DPCs) are bulky lesions that interfere with DNA metabolism and therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in S phaseExpand
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Activation of the ATR kinase by the RPA-binding protein ETAA1
Activation of the ATR kinase following perturbations to DNA replication relies on a complex mechanism involving ATR recruitment to RPA-coated single-stranded DNA via its binding partner ATRIP andExpand
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Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links
Uncrossing covalently linked DNA strands DNA interstrand cross-links (ICLs) covalently link the two strands of the double helix. ICL mutations are difficult to repair, because the two DNA strandsExpand
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CRL2Lrr1 promotes unloading of the vertebrate replisome from chromatin during replication termination.
A key event during eukaryotic replication termination is the removal of the CMG helicase from chromatin. CMG unloading involves ubiquitylation of its Mcm7 subunit and the action of the p97 ATPase.Expand
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Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair
DNA interstrand crosslinks (ICLs) are toxic DNA lesions whose repair occurs in the S phase of metazoans via an unknown mechanism. Here, we describe a cell-free system based on Xenopus egg extractsExpand
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