Markus M. Luedi

Learn More
BACKGROUND Despite an aggressive therapeutic approach, the prognosis for most patients with glioblastoma (GBM) remains poor. The aim of this study was to determine the significance of preoperative MRI variables, both quantitative and qualitative, with regard to overall and progression-free survival in GBM. METHODS We retrospectively identified 94(More)
With pilonidal sinus disease (PSD) incidence increasing and patients freely choosing their surgeon, patients’ interest issues have been brought forward estimating patient satisfaction following pilonidal sinus surgery. The influence of wound healing time and long-term recurrence rate on patient satisfaction in primary PSD surgery has not been investigated(More)
BACKGROUND Pilonidal sinus disease is thought to be caused by intrusion of hair into healthy skin; loose hair in the intergluteal fold is thought to promote disease. However, compelling evidence to support these postulates is lacking; the cause of pilonidal sinus disease remains uncertain. OBJECTIVE To determine whether particular properties of hair are(More)
BACKGROUND In elderly, high-risk patients, operating room (OR) turnaround times are especially difficult to estimate, and the managerial implications of patient age and ASA physical status for OR management decisions remain unclear. We hypothesized that evaluating patient age and ASA physical status in the right model would improve accuracy of turnaround(More)
BACKGROUND Dexamethasone is reported to induce both tumor-suppressive and tumor-promoting effects. The purpose of this study was to identify the genomic impact of dexamethasone in glioblastoma stem cell (GSC) lines and its prognostic value; furthermore, to identify drugs that can counter these side effects of dexamethasone exposure. METHODS We utilized 3(More)
The most important psychoactive constituent of CANNABIS SATIVA L. is Δ (9)-tetrahydrocannabinol (THC). Cannabidiol (CBD), another important constituent, is able to modulate the distinct unwanted psychotropic effect of THC. In natural plant extracts of C. SATIVA, large amounts of THC and CBD appear in the form of THCA-A (THC-acid-A) and CBDA (cannabidiolic(More)
STUDY OBJECTIVE To assess the effect of the kind of anesthesia on postoperative pain and long term recurrence rate in pilonidal sinus disease. DESIGN Retrospective study. SETTING Surgical departments of German Armed Forces Hospitals in Hamburg, Bad Zwischenahn and Hamm. PATIENTS 583 pilonidal sinus disease (PSD) surgery patients operated for pilonidal(More)
We have studied the recent Italian guidelines on the management of Pilonidal Sinus Disease (PSD) published in Techniques in Coloproctology [1] with interest. Guidelines serve multiple purposes but predominantly aim to reduce inappropriate variation in practice. Achieving a balance between empirical evidence, interpretation of research and individual(More)
BACKGROUND Penetrating brain injuries caused by explosions are survived in extremely rare cases only. However, potential casualties of such cases may be encountered by regular physicians even outside a war zone, e.g., due to an assault or terror blast. There is very limited literature to this end; therefore, we report the successful neurosurgical management(More)