Markus J. Kaiser

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Proxy servers are common solutions to relieve organizational networks from heavy traffic by storing the most frequently referenced web objects in their local cache. These proxies are commonly known as cooperative proxy systems and are usually organized in such a way as to optimize the utilization of their storage capacity. However, the design of the(More)
We have shown previously that our Adaptive Distributed Caching (ADC) algorithm is able to compete with typical hashing based approaches in the realm of distributed proxy systems. In our first approach, we allowed the algorithm to run with the assumption of unlimited system resources (e.g. physical RAM). In this paper we introduce an extension to ADC, which(More)
A series of aminoglycoside-capped macrocyclic structures has been prepared using intramolecular bis-tethering of neomycin on three aromatic platforms (phenanthroline, acridine, quinacridine). Based on NMR and calculations studies, it was found that the cyclic compounds adopt a highly flexible structure without conformational restriction of the(More)
Viticulture in Europe and other parts of the world is continuously suffering significant economic loss from downy mildew epidemics. Although the infection biology of the pathogen Plasmopara viticola is well understood, little is known on the population diversity of this oomycete and on the mechanisms responsible for compatible or incompatible reactions with(More)
Telomerase is the enzyme that maintains the length of telomeres. It is minimally constituted of two components: a core reverse transcriptase protein (hTERT) and an RNA (hTR). Despite its significance as an almost universal cancer target, the understanding of the structure of telomerase and the optimization of specific inhibitors have been hampered by the(More)
A self-organized approach to manage a distributed proxy system called Adaptive Distributed Caching (ADC) has been proposed previously. We model each proxy as an autonomous agent that is equipped to decide how to deal with client requests using local information. Experimental results show that our ADC algorithm is able to compete with typical hashing based(More)
With the increasing size of the Internet, proxy servers have emerged as a feasible way to reduce the overall network load and latency. More recently researchers focused on new ways to combine multiple cooperative proxies into one transparent proxy system to further increase the overall performance gain, but no work so far was really able to propose an ideal(More)
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