Markus Gonser

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AIMS The aim of this study was to investigate the current prenatal "off-label use" of cytomegalovirus hyperimmunoglobulin (CMV-HIG) in the prevention and treatment of congenital CMV (cCMV) infection, including the long-term outcome of the children. METHODS This retrospective observational study comprised mothers and their children, born between January 1,(More)
With aqueous hypochlorite and a phase transfer catalyst, secondary alcohols undergo hitherto unreported free radical reactions that compete with and effectively limit traditional ketone syntheses. Product mixture profiles are determined by reactant ratios, organic cosolvent, and availability of oxygen to the system. Under argon, over half of substrate(More)
  • M Gonser
  • 1995
Traditional protocols for oxytocin infusion regimens recommend increases of infusion rate at 15-20 min intervals. However recent clinical studies agree that prolonged intervals of 30-40 or even 60 minutes are superior to shorter dosage intervals in terms of safety and efficacy. These results are in good agreement with recent pharmacologic data on oxytocin(More)
OBJECTIVE Fetal sex determination by ultrasound, and its medical and ethical implications, has been predominantly discussed in mid and late gestation. The development of high resolution ultrasound equipment has provided the possibility of detailed visualization of the fetus in early pregnancy. The present prospective study investigates the feasibility and(More)
This study was undertaken to test the accuracy of formulas we recently developed for the sonographic estimation of the weight of very preterm fetuses. The formulas were used to determine estimated weights from prenatal sonographic data for 62 premature infants born at 23-29 weeks of gestation, weight < or = 1,400 g. The mean absolute deviation of the actual(More)
AIM In pregnancies with unilateral placental location, the uteroplacental Doppler flow measurements show significant side-to-side differences. Highly divergent findings seem to be associated with an unfavourable outcome, particularly with preeclampsia. Therefore, we studied the relationship between placental location and subsequent development of(More)
The diagnostic value (efficiency) of Doppler ultrasound in obstetrics is assessed by studying the association or correlation between Doppler measurement parameters and pregnancy outcome parameters, without influencing the clinical management. The clinical value (efficacy) is however assessed by studying the ability to improve the outcome of pregnancy if(More)
A fetus, although semi-allogeneic, is usually accepted by the maternal immune system. However, complications, including alloresponsive mechanisms, are thought to be potentially detrimental for a successful pregnancy. Therefore, we compared allogeneic T cell responses of nonpregnant women with the response of healthy pregnant women and pregnant women who(More)