Markus D. Boos

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The Id2 transcriptional repressor is essential for development of natural killer (NK) cells, lymphoid tissue-inducing (LTi) cells, and secondary lymphoid tissues. Id2 was proposed to regulate NK and LTi lineage specification from multipotent progenitors through suppression of E proteins. We report that NK cell progenitors are not reduced in the bone marrow(More)
Multiple sclerosis is an immune-mediated brain disease ameliorated by interferon-beta therapy. Immune responses to IFN-alpha and IFN-beta are sometimes subnormal in MS peripheral blood mononuclear cells (MNCs), suggesting an underlying defect in type I IFN signaling. We studied IFN-beta regulation of mRNA and protein induction for IFN regulatory factor-1(More)
BACKGROUND Id3 is a dominant antagonist of E protein transcription factor activity that is induced by signals emanating from the alphabeta and gammadelta T cell receptor (TCR). Mice lacking Id3 were previously shown to have subtle defects in positive and negative selection of TCRalphabeta+ T lymphocytes. More recently, Id3(-/-) mice on a C57BL/6 background(More)
Background: Id3 is a dominant antagonist of E protein transcription factor activity that is induced by signals emanating from the ab and cd T cell receptor (TCR). Mice lacking Id3 were previously shown to have subtle defects in positive and negative selection of TCRab + T lymphocytes. More recently, Id3 2/2 mice on a C57BL/6 background were shown to have a(More)
A 4-year-old boy developed a headache. Initial evaluation revealed a normal neurologic examination and a right subdural hygroma on CT. Worsening headaches led to hospitalization at an outside institution. MRI showed leptomeningeal enhancement; magnetic resonance angiography (MRA) was normal. Infectious, rheumatologic, hematologic, and CSF studies were(More)
Diagnosis: Coexistent Cryptococcus neoformans and Kaposi sarcoma in a patient with AIDS. Histopathologic examination revealed multiple budding yeast forms surrounded by a clear halo (Figure 1A). Grocott-methamine-silver and mucicarmine (Figure 1B) stains highlighted these organisms and their capsules, respectively. A proliferation of atypical spindle cells(More)
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