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It is widely accepted that tissue differentiation and morphogenesis in multicellular organisms are regulated by tightly controlled concentration gradients of morphogens. How exactly these gradients are formed, however, remains unclear. Here we show that Fgf8 morphogen gradients in living zebrafish embryos are established and maintained by two essential(More)
Analysis of receptor-ligand interactions in vivo is key to biology but poses a considerable challenge to quantitative microscopy. Here we combine static-volume, two-focus and dual-color scanning fluorescence correlation spectroscopy to solve this task at cellular resolution in complex biological environments. We quantified the mobility of fibroblast growth(More)
INTRODUCTION Data on prehospital and trauma-room fluid management of multiple trauma patients with pelvic disruptions are rarely reported. Present trauma algorithms recommend early hemorrhage control and massive fluid resuscitation. By matching the German Pelvic Injury Register (PIR) with the TraumaRegister DGU (TR) for the first time, we attempt to assess(More)
For a parallel manipulator with a kinematic loop and a highly flexible link, a comprehensive control approach including friction compensation for the drive train, gain scheduling and active oscillation damping is considered. Friction compensation based on the Stribeck as well as the LuGre models and gain scheduling are used to improve the position control.(More)
BACKGROUND Anterior bone grafts are used as struts to reconstruct the anterior column of the spine in kyphosis or following injury. An incomplete fusion can lead to later correction losses and compromise further healing. Despite the different stabilizing techniques that have evolved, from posterior or anterior fixating implants to combined(More)
Global sensitivity analysis is an important tool for uncertainty analysis of systems with uncertain model parameters. A general framework for the determination of sensitivity measures for fuzzy uncertainty analysis is presented. The derivation is founded on the high-dimensional model representation, which provides a common basis with Sobol indices,(More)
BACKGROUND In Germany, hospitals can deliver data from patients with pelvic fractures selectively or twofold to two different trauma registries, i.e. the German Pelvic Injury Register (PIR) and the TraumaRegister DGU(®) (TR). Both registers are anonymous and differ in composition and content. We describe the methodological approach of linking these(More)
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