Markus Bleckwenn

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What makes a general anesthetic a general anesthetic? We shall review first what general anesthesia is all about and which drugs are being used as anesthetics. There is neither a unique definition of general anesthesia nor any consensus on how to measure it. Diverse drugs and combinations of drugs generate general anesthetic states of sometimes very(More)
Why search for mechanisms of anaesthesia? General anaesthesia has become so safe since its introduction just over 150 years ago that the risk associated with it has become almost immeasurably small: less than one death solely attributable to anaesthesia occurs per 200 000 procedures. 16 This progress has been achieved in the absence of generally accepted(More)
BACKGROUND The incidence of initial prescriptions of opioids for chronic non-cancer pain rose by 37% in Germany from 2000 to 2010. Prescribing practice does not always conform with the recommendations of current guidelines. In the USA, 8-12% of patients with chronic non-cancer pain are opioid-dependent. METHODS This review is based on publications(More)
BACKGROUND Late-life depression is frequently accompanied by cognitive impairments. OBJECTIVE Whether these impairments indicate a prodromal state of dementia, or are a symptomatic expression of depression per se is not well-studied. METHODS In a cohort of very old initially non-demented primary care patients (n = 2,709, mean age = 81.1 y), cognitive(More)
Chronic recurrent multifocal osteomyelitis is a form of non-bacterial osteomyelitis which occurs primarily in childhood. In some cases painful bone swelling occurs. After a malignancy has been ruled out, antibiotic therapy is often started to treat the osteomyelitis. The course of this benign disease is self-limiting and is not positively affected by the(More)
BACKGROUND Arteriosclerotic disorders increase the risk of dementia. As they have common causes and risk factors, coronary heart disease (CHD) could influence the course of dementia. AIM To determine whether CHD increases the speed of cognitive decline in Alzheimer's disease, and to discuss the potential for secondary cardiovascular prevention to modify(More)
BACKGROUND The reasons for, and the extent of, misuse of prescribed substitution medication as well as parallel consumption of other drugs during substitution-based therapy have still not been adequately researched in Germany. METHODS This study examines the use of substitution medication in German substitution clinics utilizing a nationwide survey with(More)
BACKGROUND General practitioners (GPs) play an important role in end-of-life care due to their proximity to the patient's dwelling-place and their contact to relatives and other care providers. METHODS In order to get a better understanding of the role which the GP sees him- or herself as playing in end-of-life care and which care their dying patients(More)