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Genome-guided design of a defined mouse microbiota that confers colonization resistance against Salmonella enterica serovar Typhimurium

• Sandrine Brugiroux, Markus Beutler, +18 authors Bärbel Stecher
• Nature Microbiology
• 2016

Protection against enteric infections, also termed colonization resistance, results from mutualistic interactions of the host and its indigenous microbes. The gut microbiota of humans and mice is… (More)

Functional Intestinal Bile Acid 7α-Dehydroxylation by Clostridium scindens Associated with Protection from Clostridium difficile Infection in a Gnotobiotic Mouse Model

• Nicolas Studer, Lyne Desharnais, +10 authors Siegfried Hapfelmeier
• Front. Cell. Infect. Microbiol.
• 2016

Bile acids, important mediators of lipid absorption, also act as hormone-like regulators and as antimicrobial molecules. In all these functions their potency is modulated by a variety of chemical… (More)

Tyrosinekinase inhibition facilitates cooperation of transcription factor SALL4 and ABC transporter A3 towards intrinsic CML cell drug resistance.

• Timo Hupfeld, Bjoern Chapuy, +9 authors Gerald G. Wulf
• British journal of haematology
• 2013

Although BCR-ABL1 tyrosine kinase inhibitors reliably induce disease remission for patients with chronic myeloid leukaemia (CML), unlimited extension of therapy is necessary to prevent relapse from… (More)

Reporters for Single-Cell Analysis of Colicin Ib Expression in Salmonella enterica Serovar Typhimurium

• Stefanie Spriewald, Jana Glaser, Markus Beutler, Martin Köppel, Bärbel Stecher, Eric Cascales
• PloS one
• 2015

Colicins are toxins that mediate interference competition in microbial ecosystems. They serve as a "common good" for the entire producer population but are synthesized by only few members which pay… (More)

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