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Zea mays (L.) histone deacetylase HD2 was identified as a new type of histone deacetylase (HDAC) unrelated to the well-known Rpd3p and Hda1p families but with sequence homology to peptidyl-prolyl cis-trans isomerases (PPIases). Here we show that HD2 is a multigene family with highly related members in various plant species. Gene analysis revealed a similar(More)
In eukaryotic organisms, acetylation of core histones plays a key role in the regulation of transcription. Multiple histone acetyltransferases (HATs) and histone deacetylases (HDACs) maintain a dynamic equilibrium of histone acetylation. The latter form a highly conserved protein family in many eukaryotic species. In this paper, we report the cloning and(More)
Recently, Markov Chain Monte Carlo (MCMC) sampling methods have evolved as new promising solutions to both multiuser and multiple-input multiple-output (MIMO) detection problems. Approaches based on Gibbs sampling as a special type of MCMC methods are well suited due to their good trade-off between performance and complexity. However, it is known that(More)
We have studied enzymes involved in histone arginine methylation in the filamentous fungus Aspergillus nidulans. Three distinct protein arginine methyltransferases (PRMTs) could be identified, which all exhibit intrinsic histone methyltransferase activity when expressed as glutathione S-transferase (GST) fusion proteins. Two of these proteins, termed RmtA(More)
We have partially purified and characterized histone deacetylases of the plant pathogenic fungus Cochliobolus carbonum. Depending on growth conditions, this fungus produces HC-toxin, a specific histone deacetylase inhibitor. Purified enzymes were analyzed by immunoblotting, by immunoprecipitation, and for toxin sensitivity. The results demonstrate the(More)
The Crk-associated tyrosine kinase substrate p130cas (CAS) is a docking protein containing an SH3 domain near its N terminus, followed by a short proline-rich segment, a large central substrate domain composed of 15 repeats of the four amino acid sequence YxxP, a serine-rich region and a carboxy-terminal domain, which possesses consensus binding sites for(More)
We address the problem of how to use a priori information of data symbols to improve signal-to-noise ratio (SNR) estimation. Digital transmission with binary phase-shift keying (BPSK) over additive white Gaussian noise (AWGN) channels serves as a background. At the receive side, both pilot and data symbols are used to estimate the SNR. In addition, we(More)
We consider the design of a block equalizer for an intersymbol interference channel, given that the channel impulse response is not perfectly known at the receiver. In contrast to other schemes, our receiver is designed for imperfect channel state information and incorporates the statistics of the channel estimation error. In particular, we suggest an error(More)
The blockade of VEGF pathway has been clinically validated as an initial treatment for renal cell carcinoma (RCC). Angiopoietin-2 (Ang-2) has been indicated as a key regulator for angiogenesis escape. The effect of a novel bispecific antibody (A2V CrossMab) against both Ang-2 and VEGF was investigated in comparison with either factor. A2V CrossMab(More)