Marko T Haverinen

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PURPOSE Aging diminishes the ability to run fast, but the specific mechanisms responsible for this deterioration remain largely unknown. In the present study, we investigated the age-related decline in sprint running ability through a cross-sectional examination of biomechanical and skeletal muscle characteristics in 77 competitive male sprinters aged 17-82(More)
Muscle strength and mass decline in sedentary individuals with aging. The present study investigated the effects of both age and 21 weeks of progressive hypertrophic resistance training (RT) on skeletal muscle size and strength, and on myostatin and myogenin mRNA expression in 21 previously untrained young men (26.0 ± 4.3 years) and 18 older men (61.2 ± 4.1(More)
Almost 30 years have passed since the original demonstration that steroid receptors, comprising a subfamily of the nuclear receptor (NR) superfamily, exist as large (6-8S) non-DNA-binding complexes in hypotonic extracts (cytosol) of target cells; later such complexes were shown to correspond to a heterooligomer composed of receptor, heat shock (Hsp), and(More)
AIM This article was designed to study an interaction effect of time of day and test order-related confounding factors on daily variation in maximum muscle strength and power. METHODS Seventeen untrained men were randomized into four groups and measured at four time points (08:00 a.m., 12:00 a.m., 04:00 p.m. and 08:00 p.m.) throughout one or two days.(More)
In cell extracts all of the nonliganded steroid receptor molecules are found as an oligomeric complex with Hsp90 and other proteins. In previous studies we have shown that Wild-type Hsp90 and progesterone receptor (PR) are located in different cell compartments (Tuohimaa et al. [1993] Proc. Natl. Acad. Sci. USA 90:5848-5852). In the present work we studied(More)
Steroid receptors exist as large oligomeric complexes in hypotonic cell extracts. In the present work, we studied the nuclear transport of the 2 major components of the oligomeric complex, the receptor itself and the heat shock protein 90 (Hsp90), by using different in vitro transport systems: digitonin permeabilized cells and purified nuclei. We(More)
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