Marko Fiege

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Human malignant hyperthermia is a life-threatening genetic sensitivity of skeletal muscles to volatile anaesthetics and depolarizing neuromuscular blocking drugs occurring during or after anaesthesia. The skeletal muscle relaxant dantrolene is the only currently available drug for specific and effective therapy of this syndrome in man. After its(More)
Serotonin (5-hydroxytryptamine, 5-HT) is a biogenic amine that is distributed widely in various body tissues and cell types 1 and possesses a diversity of pharmacological effects at both central and peripheral sites. 5-HT is involved in the control of temperature regulation, cardiovascular function, muscle contraction and endocrine regulation. Peripherally,(More)
BACKGROUND 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") can mediate acute toxic effects such as muscle rigidity, metabolic acidosis, and hyperthermia. Because of close clinical similarities, an association between MDMA intoxication and malignant hyperthermia (MH) was suggested. The aim of this study was to investigate whether MDMA is a trigger of MH(More)
UNLABELLED Standardization of the in vitro contracture test (IVCT) for malignant hyperthermia (MH) susceptibility has resulted in very rare false negative tests. However, false positive results stigmatizing the patient seem to be more frequent than false negative results and make supplementary tests desirable. This multicenter approach studied the(More)
BACKGROUND Theophylline was shown to induce contracture development in porcine malignant hyperthermia (MH) susceptible (MHS) skeletal muscles in vitro. The purpose of the current study was to investigate the in vivo effects of theophylline in MHS and MH normal (MHN) swine. METHODS MH-trigger-free general anesthesia was performed in MHS and MHN swine.(More)
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