Markku Pasanen

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Incapacitating and irritating agents produce temporary disability persisting for hours to days after the exposure. One can be exposed to these agents occupationally in industrial or other working environments. Also general public can be exposed in special circumstances, like industrial accidents or riots. Incapacitating and irritating agents discussed in(More)
BACKGROUND AND OBJECTIVES Oxycodone is the mo st commonly used opioid for the treatment of moderate to severe pain. The peak cerebrospinal fluid concentration after epidural oxycodone was reported to be 300-fold greater (0.025 mM) than when administered intravenously after gynecologic surgery. Additionally, those patients administered epidural oxycodone had(More)
[1]. We totally agree with Parsons that the choice of appropriate cell model is of paramount importance in in vitro drug toxicity testing [2]. Moreover, using at least two cell lines and two toxicity assays is endorsed in order to have more accurate and relevant interpretation of drug toxicity for clinical use. In our study, we have used the SH-SY5Y and(More)
Detrimental effects of maternal smoking on the term placental proteome and steroid-metabolizing activities, and maternal hormone levels, were studied by using seven non-smoker and seven smoker placentae. Smoking significantly affected 18% of protein spots. The functional networks affected were i) cell morphology, cellular assembly and organization, cellular(More)
A workshop was convened to discuss best practices for the assessment of drug-induced liver injury (DILI) in clinical trials. In a breakout session, workshop attendees discussed necessary data elements and standards for the accurate measurement of DILI risk associated with new therapeutic agents in clinical trials. There was agreement that in order to(More)
Finland In vitro approaches in evaluation and prediction of drug-drug interactions involving the inhibition of cytochrome P450 enzymes by XIA WEN ACADEMIC DISSERTATION To be presented, with the permission of the Medical Faculty of the University of Helsinki, for public examination in the small lecture hall 2 of Biomedicum Helsinki, Haartamaninkatu 8,
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