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  • Fong Cheng Pan, Eric D Bankaitis, +5 authors Christopher V E Wright
  • Biology, Medicine
  • Development
  • 2013 (First Publication: 15 February 2013)
  • Pancreatic multipotent progenitor cells (MPCs) produce acinar, endocrine and duct cells during organogenesis, but their existence and location in the mature organ remain contentious. We usedContinue Reading
  • Anne Hoorens, Mark van de Casteele, Günter Klöppel, Daniel G Pipeleers
  • Biology, Medicine
  • The Journal of clinical investigation
  • 1996 (First Publication: 1 October 1996)
  • This study demonstrates that rat islet beta cells constitutively express an apoptotic program which is activated when mRNA or protein synthesis is blocked. Apoptotic beta cells were detectable byContinue Reading
  • Yves Heremans, Mark van de Casteele, +5 authors Harry Heimberg
  • Medicine, Biology
  • The Journal of cell biology
  • 2002 (First Publication: 28 October 2002)
  • Regulatory proteins have been identified in embryonic development of the endocrine pancreas. It is unknown whether these factors can also play a role in the formation of pancreatic endocrine cellsContinue Reading
  • Benjamin Ate Kefas, Yun-qing Cai, +4 authors Mark van de Casteele
  • Biology, Medicine
  • Journal of molecular endocrinology
  • 2003 (First Publication: 1 April 2003)
  • We have recently shown that conditions known to activate AMP-activated protein kinase (AMPK) in primary beta-cells can trigger their apoptosis. The present study demonstrates that this is also theContinue Reading
  • Geert A Martens, Ying Cai, Simon A. Hinke, Geert M Stangé, Mark van de Casteele, Daniel G Pipeleers
  • Medicine, Biology
  • Journal of Biological Chemistry
  • 2005 (First Publication: 27 May 2005)
  • High rates of glucose metabolism and mitochondrial electron transport have been associated with increased mitochondrial production of reactive oxygen species (ROS). This mechanism was also proposedContinue Reading
  • Joris van Arensbergen, Javier García-Hurtado, +7 authors Jorge Ferrer
  • Biology, Medicine
  • Genome research
  • 2010 (First Publication: 1 June 2010)
  • The epigenome changes that underlie cellular differentiation in developing organisms are poorly understood. To gain insights into how pancreatic beta-cells are programmed, we profiled key histoneContinue Reading
  • Peter Huypens, Erik Quartier, Daniël Pipeleers, Mark van de Casteele
  • Chemistry, Medicine
  • European journal of pharmacology
  • 2005 (First Publication: 1 August 2005)
  • The drugs troglitazone and metformin are used to reduce the degree of insulin resistance in type 2 diabetes. Both compounds act through different mechanisms which might include opposing effects onContinue Reading