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  • Lisa M. Pratt, Raymond Paul Beckett, +16 authors Mark Whittaker
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 1998 (First Published: 1 June 1998)
  • Matrix metalloproteinase inhibitors of general formula (1) were synthesised by a route involving an Ireland-Claisen rearrangement which enables systematic modification of the substituent alpha to theContinue Reading
  • Francisco R. Marín Martín, Raymond Paul Beckett, +11 authors Mark Whittaker
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 1999 (First Published: 1 October 1999)
  • Novel sulfonamide matrix metalloproteinase inhibitors of general formula (9) were synthesised by a route involving a stereoselective conjugate addition reaction. Enzyme selectivity was found to beContinue Reading
  • Heather Tye, Stephan Georg Mueller, +9 authors Mark Whittaker
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2011
  • The discovery of a novel series of 5-HT(2C) agonists based on a tricyclic pyrazolopyrimidine scaffold is described. Compounds with good levels of in vitro potency and moderate to good levels ofContinue Reading