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Chromosome 19 has the highest gene density of all human chromosomes, more than double the genome-wide average. The large clustered gene families, corresponding high G + C content, CpG islands and density of repetitive DNA indicate a chromosome rich in biological and evolutionary significance. Here we describe 55.8 million base pairs of highly accurate(More)
Recently, a remote-sensing platform based on wireless interconnection of tiny ECG sensors called telecardiology sensor networks (TSN) provided a promising approach to perform low-cost real-time cardiac patient monitoring at any time in community areas (such as elder nursing homes or hospitals). The contribution of this research is the design of a practical(More)
This paper deals with system level design considerations for mm-size implantable electronic devices with wireless connectivity. In particular, it focuses on neural sensors as one application requiring such miniature interfaces. Common to all these implants is the need for power supply and a wireless interface. Wireless power transfer via electromagnetic(More)
Protein structural annotation and classification is an important and challenging problem in bioinformatics. Research towards analysis of sequence-structure correspondences is critical for better understanding of a protein's structure, function, and its interaction with other molecules. Clustering of protein domains based on their structural similarities(More)
Emerging known and unknown pathogens create profound threats to public health. Platforms for rapid detection and characterization of microbial agents are critically needed to prevent and respond to disease outbreaks. Available detection technologies cannot provide broad functional information about known or novel organisms. As a step toward developing such(More)
Eflords are underway at numerous sites around the world lo construct physical maps of all human chromosomes. These maps will enable researchers to locate, characterize, and eventually understand the genes lhat control human structure and function. The volume and complexity of Ihe data already generated requires a sophislicated array of compu2ational support(More)
We describe a Multiplex Primer Prediction (MPP) algorithm to build multiplex compatible primer sets to amplify all members of large, diverse and unalignable sets of target sequences. The MPP algorithm is scalable to larger target sets than other available software, and it does not require a multiple sequence alignment. We applied it to questions in viral(More)
BACKGROUND Microbial forensics is important in tracking the source of a pathogen, whether the disease is a naturally occurring outbreak or part of a criminal investigation. RESULTS A method and SPR Opt (SNP and PCR-RFLP Optimization) software to perform a comprehensive, whole-genome analysis to forensically discriminate multiple sequences is presented.(More)
Classical time-evolving spectral analysis techniques utilize a sliding window approach that fails to exploit overarching spectrotemporal structures that are known to occur in many real-world signals. In particular, many biological signals have the distinct quality of having few defining spectral characteristics. We propose an algorithm for efficiently(More)
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