Mark W. J. Ferguson

Nick L. Occleston2
Anthony D. Metcalfe2
Duncan A. McGrouther1
2Nick L. Occleston
2Anthony D. Metcalfe
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Scarring in the skin after trauma, surgery, burn or sports injury is a major medical problem, often resulting in loss of function, restriction of tissue movement and adverse psychological effects. Whilst various studies have utilised a range of model systems that have increased our understanding of the pathways and processes underlying scar formation, they(More)
There are many programs for fitting nonlinear models to experimental data, and the use of this type of software is now widespread. After fitting a model or sequence of models, these programs usually calculate x2, run, sign, F and I statistics as an aid to model discrimination and parameter estimation. The distribution of such statistics from linear(More)
Many patients are dissatisfied with scars on both visible and non-visible body sites and would value any opportunity to improve or minimise scarring following surgery. Approximately 44 million procedures in the US and 42 million procedures in the EU per annum could benefit from scar reduction therapy. A wide range of non-invasive and invasive techniques(More)
Repaired tendons may be complicated by progressive fibrosis, causing adhesion formation or tendon softening leading to tendon rupture and subsequent reduced range of motion. There are few therapies available which improve the gliding of damaged tendons in the hand. We investigate the role of Mannose 6-phosphate (M6P) in a 600 mM hypertonic solution(More)
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