Mark Ver Heyen

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Myostatin is a newly described member of the TGF-β superfamily acting as a secreted negative regulator of skeletal muscle mass in several species, but whose mode of action remains largely unknown. In the present work, we followed the myostatin mRNA and protein levels in rat soleus and extensor digitorum longus (EDL) muscles regenerating in vivo from(More)
The cardiac sarco(endo)plasmic reticulum Ca-ATPase gene (ATP2A2) encodes the following two different protein isoforms: SERCA2a (muscle-specific) and SERCA2b (ubiquitous). We have investigated whether this isoform specificity is required for normal cardiac function. Gene targeting in mice successfully disrupted the splicing mechanism responsible for(More)
Expression of the muscle-specific 2a isoform of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2) requires activation of an inefficient optional splice process at the 3' end of the primary gene transcript. The sequence elements required for this regulated splice event were studied by modifying a minigene containing the 3' end of the SERCA2 gene. An(More)
N-channel depletion and enhancement mode MISFETs with no drain current drift have been fabricated on Ga<inf>0.47</inf>In<inf>0.53</inf> As epitaxial structures grown by low pressure MOVPE. These devices use a passivation process which includes removal of native oxide from GaInAs surface followed by a Si<inf>3</inf>N<inf>4</inf> film deposition, both steps(More)
SERCA2a is the cardiac-specific isoform of Ca -ATPase of the sarcoplasmic reticulum (SR). A reduction of SERCA2a has been implicated in the contractile dysfunction of heart failure, and partial knockout of the SERCA2 gene (Atp2a2 / mice) reiterated many of the features of heart failure. Yet, mice with a mutation of Atp2a2, resulting in full suppression of(More)
Further improvement of thickness and compositional homogeneity was sought in order to increase the usable wafer area for sophisticated device production and thus reduce the manufacturing costs in low-pressure metalorganic vapor-phase epitaxy processes. The gas-foil concept for wafer rotation was used to achieve these goals. In this technique the substrate(More)
This paper describes results of a study on the monolithic integration of AlGaAs light-emitting diodes with GaAs field-effect transistors on a conductive p-GaAs substrate. Using a selective growth technique, a horizontal configuration is fabricated that allows separate optimization of the two types of devices and provides a quasi-planar surface. This(More)
A study was made o f the doping o f e p i t a x i a l GaAs f i lms w i t h Te and S i n the HC1-Ga-AsH3-Hz system a t reduced pressures us ing Te added t o the Ga source o r H2S i n j e c t e d i n the deposi t ion reg ion. For both dopants reduct i o n of the Hz pressure leads t o increased dopant concentrat ions i n the f i l m s . The use of gas phase(More)
The ATP2A2 gene encodes the sarco(endo)plasmic reticulum Ca-transport ATPase 2 (SERCA2), which is important for intracellular Ca homeostasis within eukaryotic cells. The ATP2A family of Ca ATPases establish and maintain intracellular Ca signaling stores through the ATP-dependent accumulation of cytosolic Ca into the endoplasmic/sarcoplasmic reticulum(More)
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