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Regulated transcription controls the diversity, developmental pathways and spatial organization of the hundreds of cell types that make up a mammal. Using single-molecule cDNA sequencing, we mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene(More)
There is an urgent need to improve the infrastructure supporting the reuse of scholarly data. A diverse set of stakeholders-representing academia, industry, funding agencies, and scholarly publishers-have come together to design and jointly endorse a concise and measureable set of principles that we refer to as the FAIR Data Principles. The intent is that(More)
We have determined a 2.1 A crystal structure for human mitochondrial ClpP (hClpP), the proteolytic component of the ATP-dependent ClpXP protease. HClpP has a structure similar to that of the bacterial enzyme, with the proteolytic active sites sequestered within an aqueous chamber formed by face-to-face assembly of the two heptameric rings. The hydrophobic(More)
In higher plants, three subfamilies of sucrose nonfermenting-1 (Snf1)-related protein kinases have evolved. While the Snf1-related protein kinase 1 (SnRK1) subfamily has been shown to share pivotal roles with the orthologous yeast Snf1 and mammalian AMP-activated protein kinase in modulating energy and metabolic homeostasis, the functional significance of(More)
Goals. To describe patterns of antidepressant (ADs) prescribing in community oncology practice. Patients and methods. Data were collected using an electronic medical record on all staged breast, colon, and lung cancer patients in three community-based oncology practices. The data were analyzed retrospectively, using descriptive and bivariate analyses and(More)
Daedalus is a system-level design flow for the design of multiprocessor system-on-chip (MP-SoC) based embedded multimedia systems. It offers a fully integrated tool-flow in which design space exploration (DSE), system-level synthesis, application mapping, and system prototyping of MP-SoCs are highly automated. In this paper, we describe our first industrial(More)
The high complexity of modern embedded systems impels designers of such systems to model and simulate system components and their interactions in the early design stages. It is therefore essential to develop good tools for exploring a wide range of design choices at these early stages, where the design space is very large. This paper provides an overview of(More)
In this paper, we present the Daedalus framework, which allows for traversing the path from sequential application specification to a working MP-SoC prototype in FPGA technology with the (parallelized) application mapped onto it in only a matter of hours. During this traversal, which offers a high degree of automation, guidance is provided by Daedalus'(More)
System-level simulation and design space exploration (DSE) are key ingredients for the design of multiprocessor system-on-chip (MP-SoC) based embedded systems. The efforts in this area, however, typically use ad-hoc software infrastructures to facilitate and support the system-level DSE experiments. In this paper, we present a new, generic system-level(More)