Mark T. Clunes
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Cystic Fibrosis: The Mechanisms of Pathogenesis of an Inherited Lung Disorder.
Cystic fibrosis patients exhibit lung disease consistent with a failure of innate airway defense mechanisms. The link between abnormal ion transport and disease initiation and progression is not… Expand
A2B adenosine receptors regulate the mucus clearance component of the lung's innate defense system.
- Brett M Rollins, M. Burn, +6 authors R. Tarran
- Medicine, Biology
- American journal of respiratory cell and…
- 1 August 2008
Adenosine (ADO) signaling is altered in both asthma and chronic obstructive pulmonary disease, and the A(2B) adenosine receptor (A(2B)-R) may drive pulmonary inflammation. Accordingly, it has been… Expand
Front-runners for pharmacotherapeutic correction of the airway ion transport defect in cystic fibrosis.
Although cystic fibrosis (CF) patients display multiorgan dysfunction (e.g. pancreas, gut, and lung) it is lung disease that is the leading cause of premature death in these patients. CF lung disease… Expand
Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies
Genetic variants associated with asthma pathogenesis and altered response to drug therapy are discussed. Many studies implicate polymorphisms in genes encoding the enzymes responsible for leukotriene… Expand
Introduction to section I: overview of approaches to study cystic fibrosis pathophysiology.
Mutation of the CFTR chloride channel was identified as the genetic basis of cystic fibrosis over 20 years ago; however, correlation of the pathophysiological changes occurring in CF lung disease… Expand
Integration of Epithelial Ion Transport Activities into Airway Surface Liquid Volume and Ion Composition Regulation
Using lectures to identify student misconceptions: a study on the paradoxical effects of hyperkalemia on vascular smooth muscle.
- Stephen J Bordes, J. Gandhi, +7 authors I. V. J. Murray
- Medicine, Psychology
- Advances in physiology education
- 1 March 2020
Medical students have difficulty understanding the mechanisms underlying hyperkalemia-mediated local control of blood flow. Such control mechanisms are crucial in the brain, kidney, and skeletal… Expand
When quick response codes didn’t do the trick
- Gabrielle Walcott-Bedeau, Kazzara Raeburn, Dominic Burkhardt, Mark T. Clunes
- Psychology, Medicine
- Perspectives on medical education
- 6 April 2020
Medical education programs in the United States or Canada comply with the Liaison Committee on medical education standards to ensure their graduates provide proficient medical care. One standard… Expand
Epithelial vectorial ion transport in cystic fibrosis: Dysfunction, measurement, and pharmacotherapy to target the primary deficit
- Lucy A Clunes, Naia McMillan-Castanares, +4 authors Mark T. Clunes
- SAGE open medicine
- 25 June 2020
Cystic fibrosis patients display multi-organ system dysfunction (e.g. pancreas, gastrointestinal tract, and lung) with pathogenesis linked to a failure of Cl− secretion from the epithelial surfaces… Expand