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This paper is dedicated to the memory of Dr. Emad Fatemi who was a very kind person and a truly original scientist. A numerical scheme was presented for computing incom-pressible air-water ows using the level set method. Crucial to the above method was a new iteration method for maintaining the level set function as the signed distance from the zero level(More)
In Sussman, Smereka and Osher (1994), a numerical method using the level set approach was formulated for solving incompressible two-phase ow with surface tension. In the level set approach, the interface is represented as the zero level set of a smooth function; this has the eeect of replacing the advection of density, which has steep gradients at the(More)
In this study, we investigated cardiomyocyte cytoarchitecture in a mouse model for dilated cardiomyopathy (DCM), the muscle LIM protein (MLP) knockout mouse and substantiated several observations in a second DCM model, the tropomodulin-overexpressing transgenic (TOT) mouse. Freshly isolated cardiomyocytes from both strains are characterized by a more(More)
We present a sharp interface method for computing incompressible immiscible two-phase flows. It couples the level-set and volume-of-fluid techniques and retains their advantages while overcoming their weaknesses. It is stable and robust even for large density and viscosity ratios on the order of 1000 to 1. The numerical method is an extension of the second(More)
ÐA level set method for capturing the interface between two ¯uids is combined with a variable density projection method to allow for computation of a two-phase ¯ow where the interface can merge/ break and the ¯ow can have a high Reynolds number. A distance function formulation of the level set method enables us to compute ¯ows with large density ratios(More)
Endoplasmic reticulum (ER) stresses that reduce ER protein folding activate the unfolded protein response (UPR). One effector of the UPR is the transcription factor X-box binding protein-1 (XBP1), which is expressed on ER stress-mediated splicing of the XBP1 mRNA. XBP1 induces certain ER-targeted proteins, eg, glucose-regulated protein 78 (GRP78), that help(More)
In this work we propose a new Eulerian method for handling the dynamics of a liquid and its surface attributes (for example its color). Our approach is based on a new method for interface advection that we term the Marker Level Set (MLS). The MLS method uses surface markers and a level set for tracking the surface of the liquid, yielding more efficient and(More)
Cardiovascular disease risk is higher in men than women, but the basis for this discrepancy remains controversial. Estrogenic stimulation of the myocardium or isolated cardiomyocytes has been purported to exert multiple beneficial effects associated with inhibition of maladaptive responses to pathogenic insults. This report describes a significant(More)
Mechanistic target of rapamycin complex 1 (mTORC1), necessary for cellular growth, is regulated by intracellular signaling mediating inhibition of mTORC1 activation. Among mTORC1 regulatory binding partners, the role of Proline Rich AKT Substrate of 40 kDa (PRAS40) in controlling mTORC1 activity and cellular growth in response to pathological and(More)
This study delineates a mechanism for antiapoptotic signaling initiated by atrial natriuretic peptide (ANP) stimulation leading to elevation of cGMP levels and subsequent nuclear accumulation of Akt kinase associated with zyxin, a cytoskeletal LIM-domain protein. Nuclear targeting of zyxin induces resistance to cell death coincident with nuclear(More)