Mark Spruijt

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UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GlcNAc-T I; EC is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. We have isolated two overlapping genomic DNA clones which span 18 kilobases (kb) containing a single 2.5 kb exon for GlcNAc-T I. The exon includes most of the(More)
A systematic assessment, based on an extensive literature review, of the impact of gaps and uncertainties on the results of quantitative risk assessments (QRAs) for CO(2) pipelines is presented. Sources of uncertainties that have been assessed are: failure rates, pipeline pressure, temperature, section length, diameter, orifice size, type and direction of(More)
The N-linked carbohydrate chains of the beta subunit of human chorionic gonadotropin (hCG-beta) isolated from the culture fluid of the choriocarcinoma cell line BeWo were released enzymatically by peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase F. Subsequently, the O-linked oligosaccharides were split off from the N-deglycosylated protein by mild(More)
of Papers Pharmaceutical and Biomedica Analysis Meeting Tilburg (the Netherlands), 27 November 1992 Organizing committee: Prof. Dr. U.A.T. Bdnkman (Amsterdam) Dr. J.J.M. Holthuis (Amsterdam) Dr. K. Ensing (Groningen) H. De Bree (Weesp) Dr. J.E. Paanakker (Oss) Dr. U.R. Tjaden (Leiden) Dr. R. Woestenborghs (Beerse) THE DETERMINATION OF FK-506 IN WHOLE BLOOD(More)
In the present paper heavy gas dispersion calculations were performed with OpenFoam. For a wind tunnel test case, numerical data was validated with experiments. For a full scale numerical experiment, a code to code comparison was performed with numerical results obtained from Fluent. The validation was performed in a gravity driven environment (slope),(More)
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