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In this paper, we investigate the global self-aggregation dynamics arising from local decision-based rewiring of an overlay network, used as an abstraction for an autonomic service-oriented architecture. We measure the ability of a selected set of local rules to foster self-organization of what is originally a random graph into a structured network.(More)
Patients with high-grade serous ovarian cancer (HGSC) have experienced little improvement in overall survival, and standard treatment has not advanced beyond platinum-based combination chemotherapy, during the past 30 years. To understand the drivers of clinical phenotypes better, here we use whole-genome sequencing of tumour and germline DNA samples from(More)
This paper shows how self-(*) mechanisms give rise to complex but predictable and therefore steerable global system behavior in a cooperative computing environment. The operation of and the interactions between a set of networked autonomic devices are simulated. These are used as access points to a number of services, have the ability to accept or delegate(More)
MOTIVATION Methods for detecting somatic genome rearrangements in tumours using next-generation sequencing are vital in cancer genomics. Available algorithms use one or more sources of evidence, such as read depth, paired-end reads or split reads to predict structural variants. However, the problem remains challenging due to the significant computational(More)
LMO4, a member of the LIM-only family of zinc-finger proteins, is overexpressed in a significant proportion of breast carcinomas and acts as a negative regulator of mammary epithelial differentiation. To delineate cell types within the developing mouse mammary gland that express Lmo4, we analysed different stages of mammopoiesis by immunohistochemistry.(More)
PIK3CA, the gene coding for the p110α subunit of phosphoinositide 3-kinase, is frequently mutated in a variety of human tumors including breast cancers. To better understand the role of mutant PIK3CA in the initiation and/or progression of breast cancer, we have generated mice with a conditional knock-in of the common activating mutation, Pik3ca(H1047R),(More)