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A fundamental question in cancer biology is whether cells with tumorigenic potential are common or rare within human cancers. Studies on diverse cancers, including melanoma, have indicated that only rare human cancer cells (0.1-0.0001%) form tumours when transplanted into non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice. However, the(More)
The identification and characterization of cancer stem cells might lead to more effective treatments for some cancers by focusing therapy on the most malignant cells. To achieve this goal it will be necessary to determine which cancers follow a cancer stem cell model and which do not, to address technical issues related to tumorigenesis assays, and to test(More)
In this paper, we investigate the global self-aggregation dynamics arising from local decision-based rewiring of an overlay network, used as an abstraction for an autonomic service-oriented architecture. We measure the ability of a selected set of local rules to foster self-organization of what is originally a random graph into a structured network.(More)
This paper shows how self-(*) mechanisms give rise to complex but predictable and therefore steerable global system behavior in a cooperative computing environment. The operation of and the interactions between a set of networked autonomic devices are simulated. These are used as access points to a number of services, have the ability to accept or delegate(More)
Supplementary table 1. Melanomas from 17 of 19 patients tested grew in immunocompromised mice and could almost always be serially passaged. 7 of 9 tumors (patients 193 – 214 and 308 – 376) obtained directly from patients were successfully established in NOD/SCID mice. All of the 10 tumors obtained directly from patients that were initially injected into(More)
  • Ann-Marie Patch, Elizabeth L Christie, Dariush Etemadmoghadam, Dale W Garsed, Joshy George, Sian Fereday +76 others
  • 2015
Patients with high-grade serous ovarian cancer (HGSC) have experienced little improvement in overall survival, and standard treatment has not advanced beyond platinum-based combination chemotherapy, during the past 30 years. To understand the drivers of clinical phenotypes better, here we use whole-genome sequencing of tumour and germline DNA samples from(More)
Motivation: Methods for detecting somatic genome rearrangements in tumours using next-generation sequencing are vital in cancer gen-omics. Available algorithms use one or more sources of evidence, such as read depth, paired-end reads or split reads to predict structural variants. However, the problem remains challenging due to the significant computational(More)
LMO4, a member of the LIM-only family of zinc-finger proteins, is overexpressed in a significant proportion of breast carcinomas and acts as a negative regulator of mammary epithelial differentiation. To delineate cell types within the developing mouse mammary gland that express Lmo4, we analysed different stages of mammopoiesis by immunohistochemistry.(More)