Mark Sartain

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A major challenge in metabolomics is achieving reproducible, robust chromatographic resolution with a single analytical LC/MS method for endogenous cellular metabolites, due to their diversity of chemical and physical properties. A more manageable chromatographic solution is to develop pathway-targeted analytical methods for smaller sets of metabolites.(More)
A commercial liquid chromatography/drift tube ion mobility-mass spectrometer (LC/IM-MS) was evaluated for its utility in global metabolomics analysis. Performance was assessed using 12 targeted metabolite standards where the limit of detection (LOD), linear dynamic range, resolving power, and collision cross section (Ω) are reported for each standard. Data(More)
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