Mark S. Robbins

Learn More
Electron multiplying charge coupled devices (EMCCDs) utilize impact ionization to achieve subelectron noise up to video frame rates and above. This paper describes the effects of Co irradiation on device performance parameters including the dark signal, charge transfer and multiplication gain. Devices were irradiated with different ionizing doses, and(More)
Acute administration of clonidine (10-70 microgram/kg, IP) disrupted operant behavior maintained by a fixed ratio schedule of reinforcement [1]. When chronically administered (100 microgram/kg, IP and 3 microgram/ml in drinking water) tolerance to the behavioral depressant effect developed within a few days and was complete by 14 days. Abrupt termination of(More)
This study examines the effect of muscimol, a high affinity, specific gamma-aminobutyric acid (GABA) agonist, on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas. Perfusion with low glucose (50 mg/dl) conditions resulted in basal somatostatin release of 46 +/- 4 pg/ml. Basal insulin release was less than 20(More)
Modulation of the kallikrein-kinin system (KKS) has been shown to have beneficial effects on glucose homeostasis and several other physiological responses relevant to the progression of type 2 diabetes mellitus (T2D). The importance of bradykinin and its receptors in mediating these responses is well documented, but the role of tissue kallikrein-1, the(More)
The kallikrein-kinin system (KKS) comprises a cascade of proteolytic enzymes and biogenic peptides that regulate several physiological processes. Over-expression of tissue kallikrein-1 and modulation of the KKS shows beneficial effects on insulin sensitivity and other parameters relevant to type 2 diabetes mellitus. However, much less is known about the(More)
CCDs are regularly used as imaging and spectroscopic devices on space telescopes at X-ray energies due to their high quantum efficiency and linearity across the energy range. The International X-ray Observatory’s X-ray Grating Spectrometer will also look to make use of these devices across the energy band of 0.3 keV to 1 keV. At these energies, when photon(More)
Tissue kallikrein (KLK-1), a serine protease, initiates the release of bradykinin (BK)-related peptides from low-molecular weight kininogen. KLK-1 and the BK B2 receptor (B2R) mediate beneficial effects on the progression of type 2 diabetes and renal disease, but the precise role of KLK-1 independent of its kinin-forming activity remains unclear. We used(More)
A 0.18 μm process CMOS image sensor has recently been developed by e2v technologies plc. with a 0.5 megapixel imaging area consisting of 6 × 6 μm 5T pixels. The sensor is able to provide high performance in a diverse range of applications including machine vision and medical imaging, offering good low-light performance at a video rate of up to 60 fps. The(More)
The Gaia satellite is a high-precision astrometry, photometry and spectroscopic ESA cornerstone mission, currently scheduled for launch in 2012. Its primary science drivers are the composition, formation and evolution of the Galaxy. Gaia will achieve its unprecedented accuracy requirements with detailed calibration and correction for CCD radiation damage(More)