Mark S. Miller

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Polycystic kidney disease (PKD) is a common human genetic illness. It is characterized by the formation of multiple kidney cysts that are thought to result from over-proliferation of epithelial cells. Zebrafish larvae can also develop kidney cysts. In an insertional mutagenesis screen in zebrafish, we identified 12 genes that can cause cysts in the(More)
Modafinil is an increasingly popular wake-promoting drug used for the treatment of narcolepsy, but its precise mechanism of action is unknown. To determine potential pathways via which modafinil acts, we administered a range of doses of modafinil to rats, recorded sleep/wake activity, and studied the pattern of neuronal activation using Fos(More)
Proxies are a powerful approach to implement meta-objects in object-oriented languages without having to resort to metacircular interpretation. We introduce such a meta-level API based on proxies for Javascript. We simultaneously introduce a set of design principles that characterize such APIs in general, and compare similar APIs of other languages in terms(More)
Although several variants of DNA repair genes have been identified, their functional significance has not been determined. Using samples collected from 135 cancer-free women, this study evaluated whether amino acid substitution variants of DNA repair genes contribute to ionizing radiation (IR) susceptibility as measured by prolonged cell cycle G2 delay.(More)
Mammalian cells are constantly exposed to genotoxic agents from both endogenous and exogenous sources. Genetic variability in DNA repair contributes to deficient repair and breast cancer risk. Using samples collected in an ongoing, clinic-based, case-control study (253 cases and 268 controls), we tested whether breast cancer risk is associated with four(More)
We address three common misconceptions about capability-based systems: the Equivalence Myth (access control list systems and capability systems are formally equivalent), the Confinement Myth (capability systems cannot enforce confinement), and the Irrevocability Myth (capability-based access cannot be revoked). The Equivalence Myth obscures the benefits of(More)
Mammalian cells are constantly exposed to a wide variety of genotoxic agents from both endogenous and exogenous sources. Genetic variability in DNA repair may contribute to human cancer risk. We used a case-control study design (162 cases and 302 controls) to test the association between three amino acid substitution variants of DNA repair genes (XRCC1(More)
We examined the neuronal targets in the rat brain for the novel wakefulness-promoting agent modafinil and for amphetamine using c-Fos immunohistochemistry. Both modafinil and amphetamine induced neuronal expression of c-Fos-like immunoreactivity in the paraventricular nucleus of the hypothalamus, anterior hypothalamus and central nucleus of the amygdala.(More)
The transport of flagellar precursors and removal of turnover products from the flagellar tip is mediated by intraflagellar transport (IFT) , which is essential for both flagellar assembly and maintenance . Large groups of IFT particles are moved from the flagellar base to the tip by kinesin-2, and smaller groups are returned to the base by cytoplasmic(More)
Programmers write programs, expressing plans for machines to execute. When composed so that they may cooperate, plans may instead interfere with each other in unanticipated ways. Plan coordination is the art of simultaneously enabling plans to cooperate, while avoiding hazards of destructive plan interference. For sequential computation within a single(More)