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Methamphetamine is a popular addictive drug whose use is associated with multiple neuropsychiatric adverse events and toxic to the dopaminergic and serotonergic systems of the brain. Methamphetamine-induced neuropathology is associated with increased expression of microglial cells that are thought to participate in either pro-toxic or protective mechanisms(More)
Euphoric properties of cocaine lead to the development of chronic abuse, and appear to involve the acute activation of central DA neuronal systems. This is based upon known effects of cocaine on DA neurons, and the role played by DA in reward states and self-stimulation behavior. With chronic cocaine use, neurotransmitter and neuroendocrine alterations(More)
Recent functional neuroimaging studies have examined cognitive inhibitory control, decision-making and stress regulation in heroin addiction using a cue-reactivity paradigm. Few studies have considered impairments in heroin users from an integrated perspective for evaluation of their brain functions. We hypothesized that the brain regions that are(More)
Since the mid-1990s, there have been frequent reports of individuals whose use of the computer and internet is problematic. Given the recent expansion and the expected increase in internet availability and usage in the coming years, it is important that healthcare professionals be informed about this behavior and its associated problems. Recently,(More)
Experience with the handling of spatial data on a computer led to the identification of a variety of ‘'awkward” problems, including interpolation, error estimation and dynamic polygon building and editing. Many of the problems encountered could be classified as “‘spatial adjacency” issues. The Voronoi diagram of points and line segments in the Euclidean(More)
BACKGROUND Electrical storm, multiple temporally related episodes of ventricular tachycardia (VT) or ventricular fibrillation (VF), is a frequent problem among recipients of implantable cardioverter defibrillators (ICDs). However, insufficient data exist regarding its prognostic significance. METHODS AND RESULTS This analysis includes 457 patients who(More)
F. Abe, H. Akimoto, A. Akopian, M. G. Albrow, A. Amadon, S. R. Amendolia, D. Amidei, J. Antos, S. Aota, G. Apollinari, T. Arisawa, T. Asakawa, W. Ashmanskas, M. Atac, P. Azzi-Bacchetta, N. Bacchetta, S. Bagdasarov, M. W. Bailey, P. de Barbaro, A. Barbaro-Galtieri, V. E. Barnes, B. A. Barnett, M. Barone, G. Bauer, T. Baumann, F. Bedeschi, S. Behrends, S.(More)
A nonhuman primate model for malaria vaccine development allowing reliable, stringent sporozoite challenge and evaluation of both cellular and antibody responses is needed. We therefore constructed a multicomponent, multistage DNA vaccine for the simian malaria species Plasmodium knowlesi including two preerythrocytic-stage antigens, the circumsporozoite(More)
Nicotine dependence is a chronic mental illness that is characterized by a negative affective state upon tobacco smoking cessation and relapse after periods of abstinence. It has been hypothesized that cessation of nicotine administration results in the activation of brain corticotropin-releasing factor (CRF) systems that leads to the negative affective(More)
A sample of 904 physicians consecutively admitted to 16 state Physicians' Health Programs (PHPs) was studied for 5 years or longer to characterize the outcomes of this episode of care and to explore the elements of these programs that could improve the care of other addicted populations. The study consisted of two phases: the first characterized the PHPs(More)