Mark S. Frank

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OBJECTIVE The purpose of this study was to perform a computer analysis of the size of the thermal injury created by overlapping multiple thermal ablation spheres. MATERIALS AND METHODS A computer-assisted design system was used to create three-dimensional models of a spherical tumor, a spherical tissue volume consisting of the tumor plus a 1-cm tumor-free(More)
The present study of metronidazole in perineal Crohn's disease includes 26 patients, and is composed of 17 of 21 patients who were previously reported and 9 additional consecutive patients. The course of these patients was evaluated to determine if the drug could be reduced or stopped, whether or not it continued to be effective for prolonged periods, and(More)
The effect of metronidazole was studied in 21 consecutive patients with chronic unremitting perineal Crohn's disease. Drainage, erythema, and induration diminished dramatically in all patients, and complete healing was obtained in 10 of 18 patients maintained on therapy. Five others have shown advanced healing; in 2 patients the inflammation is improved,(More)
CT performed in patients during suspended full expiration has recently been used to reveal a major physiologic consequence of airway diseases, particularly diseases of those smaller airways beyond the segmental branches: air trapping. Lung regions that retain air during exhalation (air trapping) remain more lucent than normal lung regions do. Detection of(More)
Glycerol is a potent osmotic dehydrating agent with additional effects on brain metabolism. In doses of 0.25-2.0 g/kg glycerol decreases intracranial pressure in numerous disease states, including Reye's syndrome, stroke, encephalitis, meningitis, pseudotumor cerebri, central nervous system tumor, and space occupying lesions. It is also effective in(More)
Radiology departments are beginning to embrace new technologies to decrease operating budgets and improve services. One of these technologies is the picture archiving and communication system (PACS). PACS, through immediate availability of images to the radiologist, promises to decrease turnaround times of reports to the clinician. The purpose of this study(More)
Areas of variable lung attenuation in a lobular or multilobular distribution are occasionally seen on CT or high-resolution CT scans of the lungs [1], although never as a normal finding. This mosaic pattern of lung attenuation presents a challenge to the radiologist when deciding which are the abnormal regions of lung--those of low attenuation, those of(More)