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In this work, the post-yield behaviour of cortical bone is investigated using finite element modelling, nanoindentation and atomic force microscopy. Based on recent investigations, it is proposed that, since pressure dependent deformation mechanisms may contribute to yielding in bone, constitutive models attempting to capture its post-yield behaviour should(More)
The purpose of this work is to investigate the use of indentation fracture as a method of measuring toughness at the microscale in cortical bone. Indentation fracture employs sharp indenters to initiate cracks, whose length can be used to calculate the toughness of the material. Only a cube corner indenter tip is found to initiate cracks at a suitable size(More)
In the midst of a rich environment for medical device development and manufacturing, universities can play a critical role by developing relevant training programs to produce entrepreneurs who can be efficient and successful in creating early stage companies by understanding deeply the issues involved in creating a useful device, how to raise money,(More)
Cortical bone is a heterogeneous material with a complex hierarchical microstructure. In this work, unit cell finite element models were developed to investigate the effect of microstructural morphology on the macroscopic properties of cortical bone. The effect of lacunar and vascular porosities, percentage of osteonal bone and orientation of the Haversian(More)
Haemodynamic forces have a synergistic effect on endothelial cell (EC) morphology, proliferation, differentiation and biochemical expression profiles. Alterations to haemodynamic force levels have been observed at curved regions and bifurcations of arteries but also around struts of stented arteries, and are also known to be associated with various vascular(More)
Computational simulations using finite element analysis are a tool commonly used to analyse stent designs, deployment geometries and interactions between stent struts and arterial tissue. Such studies require large computational models and efforts are often made to simplify models in order to reduce computational time while maintaining reasonable accuracy.(More)
During knee flexion, the muscles of the upper leg impose various loads on the underlying femoropopliteal artery resulting in radial compression, bending, torsion, axial extension and axial compression. Measuring the dynamic force environment of the femoropopliteal artery and quantifying its resulting deformation characteristics is an essential input to(More)
NiTi׳s superelasticity is exploited in a number of biomedical devices, in particular self-expanding endovascular stents. These stents are often laser-cut from textured micro-tubing; texture is the distribution of crystallographic grain orientations in a polycrystalline material which has been experimentally shown to have a marked influence on mechanical(More)
Cardiovascular stents are commonly made from 316L stainless steel and are deployed within stenosed arterial lesions using balloon expansion. Deployment involves inflating the balloon and plastically deforming the stent until the required diameter is obtained. This plastic deformation induces static stresses in the stent, which will remain for the lifetime(More)
Physiological loads that act on the femoropopliteal artery, in combination with stenting, can lead to uncharacteristic deformations of the stented vessel. The overall goal of this study was to investigate the effect of stent length and stent location on the deformation characteristics of the superficial femoral artery (SFA) using an anatomically accurate,(More)