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Othogonal frequency division multiplex-ing with a suitably chosen guard interval is a n effective means of eliminating intersymbol interference for high-rate transmission over fading dispersive channels. T i m e variations of t h e channel, however, lead t o a loss of subchannel orthogonality, resulting in interchannel interference (ICI). This article(More)
Members of the Dbl family of guanine nucleotide exchange factors (GEFs) have important roles in the organization of actin-based cytoskeletal structures of a wide variety of cell types. Through the activation of members of the Rho family of GTP signaling molecules, these exchange factors elicit cytoskeletal alterations that allow cellular remodeling. As(More)
Signal transduction via guanine nucleotide binding proteins (G proteins) is involved in cardiovascular, neural, endocrine, and immune cell function. Regulators of G protein signaling (RGS proteins) speed the turn-off of G protein signals and inhibit signal transduction, but the in vivo roles of RGS proteins remain poorly defined. To overcome the redundancy(More)
In a localized routing algorithm, node A currently holding the message forwards it to one or few neighbors based on the location of itself, its neighboring nodes and destination. Several localized routing algorithms for wireless networks were described recently, based on location information of nodes available via Global Positioning System (GPS). The(More)
Integrins and proteins that associate with integrins are implicated in normal cardiac muscle function and development. Unc-112 is a cytoplasmic adaptor protein required for the proper establishment of integrin junctions in Caenorhabditis elegans muscle. A vertebrate homolog of unc-112, kindlin-2, is an integrin-binding protein that is expressed in cardiac(More)
Aging is associated with hypertrophy, dilatation, and fibrosis of the left ventricle (LV) of the heart. Advances in echocardiographic assessment have made it possible to follow changes in cardiac function in a serial, noninvasive manner. The purpose was to determine whether there is echocardiographic evidence of age-associated changes in chamber dimensions(More)
Mutations that cause defects in levels of the signaling lipid phosphatidylinositol 3,5-bisphosphate [PI(3,5)P(2)] lead to profound neurodegeneration in mice. Moreover, mutations in human FIG4 predicted to lower PI(3,5)P(2) levels underlie Charcot-Marie-Tooth type 4J neuropathy and are present in selected cases of amyotrophic lateral sclerosis. In yeast and(More)
PURPOSE This study examined the effects of exercise-induced fatigue on soccer skills performed throughout simulated match play. METHODS Fifteen academy soccer players completed a soccer match simulation (SMS) including passing, dribbling, and shooting skills. Precision, success rate, and ball speed were determined via video analysis for all skills. Blood(More)
A ''book-embedding'' of a graph G comprises embedding the graph's nodes along the spine of a book and embedding the edges on the pages so that the edges embedded on the same page do not intersect. This is also referred to as the page model. The ''pagenumber'' of a graph is the thickness of the smallest (in number of pages) book into which G can be embedded.(More)
Peroxisome proliferator-activated receptor (PPAR)-gamma is required for adipogenesis but is also found in the cardiovascular system, where it has been proposed to oppose inflammatory pathways and act as a growth suppressor. PPAR-gamma agonists, thiazolidinediones (TZDs), inhibit cardiomyocyte growth in vitro and in pressure overload models. Paradoxically,(More)