Learn More
BACKGROUND Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used to promote fusion in spinal surgery, but its safety has been questioned. PURPOSE To evaluate the effectiveness and safety of rhBMP-2. DATA SOURCES Individual-participant data obtained from the sponsor or investigators and data extracted from study publications identified(More)
Appendix 2: Bibliography of methodological texts used in the production of the guidance……………………………………………………………………………………… 87 4 ACKNOWLEDGEMENTS The research reported here was funded by the ESRC (Grant reference number H33250019) within the ESRC Methods Programme. There are many people who have contributed to this work along the way to whom we would like to(More)
This report describes the development of a method to detect the waterborne pathogen Aeromonas using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). The genus Aeromonas is one of several medically significant genera that have gained prominence due to their evolving taxonomy and controversial role in human diseases. In this study,(More)
domestic smoke alarms save lives? Can young offenders be 'scared straight' through tough penal measures? What factors should be considered when designing and implementing a multi-sectoral injury prevention programme in a local area? Making sense of large bodies of evidence drawn from research using a range of methods is a challenge. Ensuring that the(More)
BACKGROUND Etanercept, infliximab and adalimumab are licensed in the UK for the treatment of active and progressive psoriatic arthritis (PsA) in adults who have an inadequate response to standard treatment. OBJECTIVE To determine the clinical effectiveness, safety and cost-effectiveness of these biologic agents in the treatment of active and progressive(More)
OBJECTIVE Case series can influence clinical practice but are often omitted from systematic reviews. We evaluated the contribution of case series to a systematic review of radiofrequency catheter ablation (RFCA) for treatment of atrial fibrillation (AF). STUDY DESIGN AND SETTING Analysis of the results of a systematic review based on a search of 25(More)
OBJECTIVE To assess the cost-effectiveness of radiofrequency catheter ablation (RFCA) compared with anti-arrhythmic drug (AAD) therapy for the treatment of atrial fibrillation (AF) from the perspective of the UK NHS. DESIGN Bayesian evidence synthesis and decision analytical model. METHODS A systematic review and meta-analysis was conducted and Bayesian(More)
OBJECTIVES To determine the safety, clinical effectiveness and cost-effectiveness of radio frequency catheter ablation (RCFA) for the curative treatment of atrial fibrillation (AF) and typical atrial flutter. DATA SOURCES For the systematic reviews of clinical studies 25 bibliographic databases and internet sources were searched in July 2006, with(More)
OBJECTIVES To determine the most effective diagnostic strategy for the investigation of microscopic and macroscopic haematuria in adults. DATA SOURCES Electronic databases from inception to October 2003, updated in August 2004. REVIEW METHODS A systematic review was undertaken according to published guidelines. Decision analytic modelling was(More)