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BACKGROUND Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used to promote fusion in spinal surgery, but its safety has been questioned. PURPOSE To evaluate the effectiveness and safety of rhBMP-2. DATA SOURCES Individual-participant data obtained from the sponsor or investigators and data extracted from study publications identified(More)
Appendix 2: Bibliography of methodological texts used in the production of the guidance……………………………………………………………………………………… 87 4 ACKNOWLEDGEMENTS The research reported here was funded by the ESRC (Grant reference number H33250019) within the ESRC Methods Programme. There are many people who have contributed to this work along the way to whom we would like to(More)
domestic smoke alarms save lives? Can young offenders be 'scared straight' through tough penal measures? What factors should be considered when designing and implementing a multi-sectoral injury prevention programme in a local area? Making sense of large bodies of evidence drawn from research using a range of methods is a challenge. Ensuring that the(More)
BACKGROUND Etanercept, infliximab and adalimumab are licensed in the UK for the treatment of active and progressive psoriatic arthritis (PsA) in adults who have an inadequate response to standard treatment. OBJECTIVE To determine the clinical effectiveness, safety and cost-effectiveness of these biologic agents in the treatment of active and progressive(More)
OBJECTIVE Case series can influence clinical practice but are often omitted from systematic reviews. We evaluated the contribution of case series to a systematic review of radiofrequency catheter ablation (RFCA) for treatment of atrial fibrillation (AF). STUDY DESIGN AND SETTING Analysis of the results of a systematic review based on a search of 25(More)
BACKGROUND Depression is the most common mental disorder in community settings and a major cause of disability across the world. The objective of treatment is to achieve remission or at least adequate control of depressive symptoms; however, even after successful treatment, the risk of relapse after remission is significant. Although the effectiveness of(More)
OBJECTIVE To investigate whether published results of industry funded trials of recombinant human bone morphogenetic protein 2 (rhBMP-2) in spinal fusion match underlying trial data by comparing three different data sources: individual participant data, internal industry reports, and publicly available journal publications and conference abstracts. DATA(More)
OBJECTIVES To determine the most effective diagnostic strategy for the investigation of microscopic and macroscopic haematuria in adults. DATA SOURCES Electronic databases from inception to October 2003, updated in August 2004. REVIEW METHODS A systematic review was undertaken according to published guidelines. Decision analytic modelling was(More)
OBJECTIVES A probabilistic model was developed to determine the cost-effectiveness of three biologics, etanercept, infliximab and adalimumab, compared with palliative care for the treatment of active and progressive PsA in patients who have an inadequate response to standard treatment (including DMARDs). METHODS A previous model was revised to evaluate(More)