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Appendix 2: Bibliography of methodological texts used in the production of the guidance……………………………………………………………………………………… 87 4 ACKNOWLEDGEMENTS The research reported here was funded by the ESRC (Grant reference number H33250019) within the ESRC Methods Programme. There are many people who have contributed to this work along the way to whom we would like to(More)
BACKGROUND Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used to promote fusion in spinal surgery, but its safety has been questioned. PURPOSE To evaluate the effectiveness and safety of rhBMP-2. DATA SOURCES Individual-participant data obtained from the sponsor or investigators and data extracted from study publications identified(More)
domestic smoke alarms save lives? Can young offenders be 'scared straight' through tough penal measures? What factors should be considered when designing and implementing a multi-sectoral injury prevention programme in a local area? Making sense of large bodies of evidence drawn from research using a range of methods is a challenge. Ensuring that the(More)
OBJECTIVE To investigate whether published results of industry funded trials of recombinant human bone morphogenetic protein 2 (rhBMP-2) in spinal fusion match underlying trial data by comparing three different data sources: individual participant data, internal industry reports, and publicly available journal publications and conference abstracts. DATA(More)
BACKGROUND The grading of recommendation, assessment, development and evaluation (GRADE) approach is widely implemented in health technology assessment and guideline development organisations throughout the world. GRADE provides a transparent approach to reaching judgements about the quality of evidence on the effects of a health care intervention, but is(More)
Table to show the quality of systematic reviews of psychosocial interventions in heart disease and cancer (to be considered systematic, reviews had to meet a minimum of two specific criteria) References Reviewing the results of systematic reviews: Number of quality criteria met (maximum = 7) 2 3 4 5 6 7 Total Cancer 2 6 9 3 1 0 21 Heart disease 1 1 2 1 2 1(More)
OBJECTIVE To identify the main areas of uncertainty and subsequent research priorities to inform the ongoing debate around assisted dying. DESIGN Two-round electronic modified Delphi consultation with experts and interested bodies. SETTING AND PARTICIPANTS 110 groups and individuals interested in the subject of end-of-life care and/or assisted dying(More)
BACKGROUND Research has indicated that adverse effects terms are increasingly prevalent in the title, abstract or indexing terms of articles that contain adverse drug effects data in MEDLINE and Embase. However, it is unknown whether adverse effects terms are present in the database records of articles that contain adverse effects data of medical devices,(More)
To the editor, On behalf of my co-authors I have submitted the manuscript " The safety and efficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2) for spinal fusion: An individual patient data meta-analysis " for consideration by Annals of Internal Medicine. This paper is drawn form a wider report on the same topic performed by the Centre for(More)
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