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domestic smoke alarms save lives? Can young offenders be 'scared straight' through tough penal measures? What factors should be considered when designing and implementing a multi-sectoral injury prevention programme in a local area? Making sense of large bodies of evidence drawn from research using a range of methods is a challenge. Ensuring that the(More)
OBJECTIVE To investigate whether published results of industry funded trials of recombinant human bone morphogenetic protein 2 (rhBMP-2) in spinal fusion match underlying trial data by comparing three different data sources: individual participant data, internal industry reports, and publicly available journal publications and conference abstracts. DATA(More)
BACKGROUND The grading of recommendation, assessment, development and evaluation (GRADE) approach is widely implemented in health technology assessment and guideline development organisations throughout the world. GRADE provides a transparent approach to reaching judgements about the quality of evidence on the effects of a health care intervention, but is(More)
OBJECTIVE To identify the main areas of uncertainty and subsequent research priorities to inform the ongoing debate around assisted dying. DESIGN Two-round electronic modified Delphi consultation with experts and interested bodies. SETTING AND PARTICIPANTS 110 groups and individuals interested in the subject of end-of-life care and/or assisted dying(More)
A. Developing a methodological framework for organisational case studies: a rapid review and consensus development process. Reports are published in Health Services and Delivery Research (HS&DR) if (1) they have resulted from work for the HS&DR programme or programmes which preceded the HS&DR programme, and (2) they are of a sufficiently high scientific(More)
BACKGROUND Research has indicated that adverse effects terms are increasingly prevalent in the title, abstract or indexing terms of articles that contain adverse drug effects data in MEDLINE and Embase. However, it is unknown whether adverse effects terms are present in the database records of articles that contain adverse effects data of medical devices,(More)
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